Stimulus-dependent representational drift in primary visual cortex

To produce consistent sensory perception, neurons must maintain stable representations of sensory input. However, neurons in many regions exhibit progressive drift across days. Longitudinal studies have found stable responses to artificial stimuli across sessions in visual areas, but it is unclear w...

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Bibliographic Details
Published in:Nature communications Vol. 12; no. 1; pp. 5169 - 16
Main Authors: Marks, Tyler D., Goard, Michael J.
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 27.08.2021
Nature Publishing Group
Nature Portfolio
Subjects:
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Animals
Behavior, Animal
Circuits
Correlation analysis
Drift
Female
Humanities and Social Sciences
Interneurons
Local population
Longitudinal studies
Male
Mice
Mice, Transgenic
Motion pictures
multidisciplinary
Neuroimaging
Neurons
Neurons - physiology
Photic Stimulation
Science
Science (multidisciplinary)
Sensory neurons
Sensory perception
Somatosensory cortex
Visual cortex
Visual Cortex - physiology
Visual Perception
Visual stimuli
ISSN:2041-1723, 2041-1723
Online Access:Get full text
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Summary:To produce consistent sensory perception, neurons must maintain stable representations of sensory input. However, neurons in many regions exhibit progressive drift across days. Longitudinal studies have found stable responses to artificial stimuli across sessions in visual areas, but it is unclear whether this stability extends to naturalistic stimuli. We performed chronic 2-photon imaging of mouse V1 populations to directly compare the representational stability of artificial versus naturalistic visual stimuli over weeks. Responses to gratings were highly stable across sessions. However, neural responses to naturalistic movies exhibited progressive representational drift across sessions. Differential drift was present across cortical layers, in inhibitory interneurons, and could not be explained by differential response strength or higher order stimulus statistics. However, representational drift was accompanied by similar differential changes in local population correlation structure. These results suggest representational stability in V1 is stimulus-dependent and may relate to differences in preexisting circuit architecture of co-tuned neurons. Here, the authors find that representational drift in visual cortex differs depending on the sensory stimulus, suggesting that the stability of neuronal responses is not a fixed property of individual cells, but rather depends on the encoded information.
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ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-021-25436-3