Gene therapy conversion of striatal astrocytes into GABAergic neurons in mouse models of Huntington’s disease

Huntington’s disease (HD) is caused by Huntingtin (Htt) gene mutation resulting in the loss of striatal GABAergic neurons and motor functional deficits. We report here an in vivo cell conversion technology to reprogram striatal astrocytes into GABAergic neurons in both R6/2 and YAC128 HD mouse model...

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Bibliographic Details
Published in:	Nature communications Vol. 11; no. 1; pp. 1105 - 18
Main Authors:	Wu, Zheng, Parry, Matthew, Hou, Xiao-Yi, Liu, Min-Hui, Wang, Hui, Cain, Rachel, Pei, Zi-Fei, Chen, Yu-Chen, Guo, Zi-Yuan, Abhijeet, Sambangi, Chen, Gong
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 27.02.2020 Nature Publishing Group Nature Portfolio
Subjects:	42 42/44 631/378/1689/1558 631/378/87 Action Potentials - physiology Animal models Animals Astrocytes Astrocytes - physiology Axon guidance Axons Basic Helix-Loop-Helix Transcription Factors Behavior Observation Techniques Behavior, Animal Beta2 protein Cellular Reprogramming Techniques - methods Conversion Corpus Striatum - cytology Corpus Striatum - pathology Dependovirus - genetics Disease Models, Animal Ectopic expression Ectopic Gene Expression GABAergic Neurons - physiology Gene therapy Genetic Therapy - methods Genetic Vectors - administration & dosage Genetic Vectors - genetics Globus pallidus HEK293 Cells Homeodomain Proteins Humanities and Social Sciences Humans Huntingtin Huntingtin Protein - genetics Huntington Disease - genetics Huntington Disease - pathology Huntington Disease - therapy Huntington's disease Huntingtons disease In vivo methods and tests Life span Longevity Mice Mice, Transgenic multidisciplinary Mutation Neostriatum Neurodegeneration Neurodegenerative diseases Neuronal-glial interactions Neurons Patch-Clamp Techniques Point mutation Science Science (multidisciplinary) Spiny neurons Stereotaxic Techniques Substantia nigra Time dependence Transcription Factors Transfection γ-Aminobutyric acid
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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