Metabolically healthy obesity: epidemiology, mechanisms, and clinical implications

Obesity has become a worldwide epidemic that poses substantial health problems for both individuals and society. However, a proportion of obese individuals might not be at an increased risk for metabolic complications of obesity and, therefore, their phenotype can be referred to as metabolically hea...

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Vydáno v:The lancet. Diabetes & endocrinology Ročník 1; číslo 2; s. 152
Hlavní autoři: Stefan, Norbert, Häring, Hans-Ulrich, Hu, Frank B, Schulze, Matthias B
Médium: Journal Article
Jazyk:angličtina
Vydáno: England 01.10.2013
Témata:
Bariatric Surgery
Body Fat Distribution
Health
Humans
Insulin Resistance
Life Style
Obesity - diagnosis
Obesity - epidemiology
Obesity - metabolism
Obesity - therapy
Observational Studies as Topic
Prognosis
Survival
Weight Reduction Programs
ISSN:2213-8595, 2213-8595
On-line přístup:Zjistit podrobnosti o přístupu
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Shrnutí:Obesity has become a worldwide epidemic that poses substantial health problems for both individuals and society. However, a proportion of obese individuals might not be at an increased risk for metabolic complications of obesity and, therefore, their phenotype can be referred to as metabolically healthy obesity. This novel concept of metabolically healthy obesity might become increasingly important to stratify individuals in the clinical treatment of obesity. However, no universally accepted criteria exist to define metabolically healthy obesity. Furthermore, many questions have been raised regarding the biological basis of this phenotype, the transitory nature of metabolically healthy obesity over time, and predictors of this phenotype. We describe the observational studies that gave rise to the idea of metabolically healthy obesity and the key parameters that can help to distinguish it from the general form of obesity. We also discuss potential biological mechanisms underlying metabolically healthy obesity and its public health and clinical implications.
Bibliografie:ObjectType-Article-1
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ISSN:2213-8595
2213-8595
DOI:10.1016/S2213-8587(13)70062-7