Metabolically healthy obesity: epidemiology, mechanisms, and clinical implications

Obesity has become a worldwide epidemic that poses substantial health problems for both individuals and society. However, a proportion of obese individuals might not be at an increased risk for metabolic complications of obesity and, therefore, their phenotype can be referred to as metabolically hea...

Full description

Saved in:
Bibliographic Details
Published in:The lancet. Diabetes & endocrinology Vol. 1; no. 2; p. 152
Main Authors: Stefan, Norbert, Häring, Hans-Ulrich, Hu, Frank B, Schulze, Matthias B
Format: Journal Article
Language:English
Published: England 01.10.2013
Subjects:
Bariatric Surgery
Body Fat Distribution
Health
Humans
Insulin Resistance
Life Style
Obesity - diagnosis
Obesity - epidemiology
Obesity - metabolism
Obesity - therapy
Observational Studies as Topic
Prognosis
Survival
Weight Reduction Programs
ISSN:2213-8595, 2213-8595
Online Access:Get more information
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Obesity has become a worldwide epidemic that poses substantial health problems for both individuals and society. However, a proportion of obese individuals might not be at an increased risk for metabolic complications of obesity and, therefore, their phenotype can be referred to as metabolically healthy obesity. This novel concept of metabolically healthy obesity might become increasingly important to stratify individuals in the clinical treatment of obesity. However, no universally accepted criteria exist to define metabolically healthy obesity. Furthermore, many questions have been raised regarding the biological basis of this phenotype, the transitory nature of metabolically healthy obesity over time, and predictors of this phenotype. We describe the observational studies that gave rise to the idea of metabolically healthy obesity and the key parameters that can help to distinguish it from the general form of obesity. We also discuss potential biological mechanisms underlying metabolically healthy obesity and its public health and clinical implications.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:2213-8595
2213-8595
DOI:10.1016/S2213-8587(13)70062-7