The plasticity of DNA replication forks in response to clinically relevant genotoxic stress

Complete and accurate DNA replication requires the progression of replication forks through DNA damage, actively transcribed regions, structured DNA and compact chromatin. Recent studies have revealed a remarkable plasticity of the replication process in dealing with these obstacles, which includes...

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Bibliographic Details
Published in:	Nature reviews. Molecular cell biology Vol. 21; no. 10; pp. 633 - 651
Main Authors:	Berti, Matteo, Cortez, David, Lopes, Massimo
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.10.2020 Nature Publishing Group
Subjects:	631/337/1427/2566 631/337/151/2353 631/337/151/2356 Adaptation Animals Barriers Biochemistry Biomedical and Life Sciences Cancer Cancer Research Carcinogenesis - genetics Care and treatment Cell Biology Chromatin Chromatin - genetics Crosstalk Deoxyribonucleic acid Developmental Biology DNA DNA - genetics DNA biosynthesis DNA damage DNA Damage - genetics DNA Replication - genetics Functional morphology Genetic aspects Genotoxicity Health aspects Humans Immunity Immunity, Innate - genetics Innate immunity Life Sciences Plastic properties Plasticity Primers (Molecular genetics) Replication Replication forks Replication Origin - genetics Replication origins Review Article Stem Cells Stress (Physiology) Structural damage Tumorigenesis Switzerland
ISSN:	1471-0072, 1471-0080, 1471-0080
Online Access:	Get full text
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