Perspective on taxonomic classification of uncultivated viruses

[Display omitted] Historically, virus taxonomy has been limited to describing viruses that were readily cultivated in the laboratory or emerging in natural biomes. Metagenomic analyses, single-particle sequencing, and database mining efforts have yielded new sequence data on an astounding number of...

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Published in:Current opinion in virology Vol. 51; no. C; pp. 207 - 215
Main Authors: Dutilh, Bas E, Varsani, Arvind, Tong, Yigang, Simmonds, Peter, Sabanadzovic, Sead, Rubino, Luisa, Roux, Simon, Muñoz, Alejandro Reyes, Lood, Cédric, Lefkowitz, Elliot J, Kuhn, Jens H, Krupovic, Mart, Edwards, Robert A, Brister, J Rodney, Adriaenssens, Evelien M, Sullivan, Matthew B
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 01.12.2021
Elsevier
Subjects:
Animals
Evolution, Molecular
Humans
Life Sciences
Metagenomics
Microbiology and Parasitology
Phylogeny
Virology
Viruses - classification
Viruses - genetics
Viruses - growth & development
ISSN:1879-6257, 1879-6265, 1879-6265
Online Access:Get full text
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Summary:[Display omitted] Historically, virus taxonomy has been limited to describing viruses that were readily cultivated in the laboratory or emerging in natural biomes. Metagenomic analyses, single-particle sequencing, and database mining efforts have yielded new sequence data on an astounding number of previously unknown viruses. As metagenomes are relatively free of biases, these data provide an unprecedented insight into the vastness of the virosphere, but to properly value the extent of this diversity it is critical that the viruses are taxonomically classified. Inclusion of uncultivated viruses has already improved the process as well as the understanding of the taxa, viruses, and their evolutionary relationships. The continuous development and testing of computational tools will be required to maintain a dynamic virus taxonomy that can accommodate the new discoveries.
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USDOE
ISSN:1879-6257
1879-6265
1879-6265
DOI:10.1016/j.coviro.2021.10.011