Clonal Architecture of Secondary Acute Myeloid Leukemia

Whole-genome sequencing of samples from seven subjects with secondary acute myeloid leukemia identified somatic mutations. These data, together with genotype analysis of the antecedent myelodysplastic syndromes (MDS), revealed the clonal evolution of MDS and secondary AML. The myelodysplastic syndro...

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Veröffentlicht in:The New England journal of medicine Jg. 366; H. 12; S. 1090 - 1098
Hauptverfasser: Walter, Matthew J, Shen, Dong, Ding, Li, Shao, Jin, Koboldt, Daniel C, Chen, Ken, Larson, David E, McLellan, Michael D, Dooling, David, Abbott, Rachel, Fulton, Robert, Magrini, Vincent, Schmidt, Heather, Kalicki-Veizer, Joelle, O'Laughlin, Michelle, Fan, Xian, Grillot, Marcus, Witowski, Sarah, Heath, Sharon, Frater, John L, Eades, William, Tomasson, Michael, Westervelt, Peter, DiPersio, John F, Link, Daniel C, Mardis, Elaine R, Ley, Timothy J, Wilson, Richard K, Graubert, Timothy A
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Waltham, MA Massachusetts Medical Society 22.03.2012
Schlagworte:
Acute myeloid leukemia
Adolescent
Adult
Biological and medical sciences
Bone marrow
Bone Marrow Cells - pathology
Cancer
Cell Transformation, Neoplastic - genetics
Clonal selection
Clone Cells
Cloning
Deoxyribonucleic acid
Disease
DNA
Gene expression
General aspects
Genome, Human
Genomes
Hematologic and hematopoietic diseases
Hematological diseases
Humans
Leukemia
Leukemia, Myeloid, Acute - etiology
Leukemia, Myeloid, Acute - genetics
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Medical sciences
Middle Aged
Mutation
Myelodysplastic syndrome
Myelodysplastic Syndromes - complications
Myelodysplastic Syndromes - genetics
Myeloid leukemia
Oligonucleotide Array Sequence Analysis
Pathogenesis
Skin
Young Adult
Medicine
Acute myelogenous leukemia
Secondary
Malignant hemopathy
Architecture
Cancer
ISSN:0028-4793, 1533-4406, 1533-4406
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Zusammenfassung:Whole-genome sequencing of samples from seven subjects with secondary acute myeloid leukemia identified somatic mutations. These data, together with genotype analysis of the antecedent myelodysplastic syndromes (MDS), revealed the clonal evolution of MDS and secondary AML. The myelodysplastic syndromes, a heterogeneous group of diseases characterized by ineffective hematopoiesis, are the most common cause of acquired bone marrow failure in adults. 1 Secondary acute myeloid leukemia (AML) develops in approximately one third of persons with myelodysplastic syndromes. 2 Clinical discrimination between the myelodysplastic syndromes and secondary AML currently rests predominantly on cytomorphologic analysis, since patients with myelodysplastic syndromes have dysplastic hematopoiesis and a myeloblast count of less than 20%, whereas those with a myeloblast count of 20% or more have AML. Although considerable overlap exists between the spectrum of cytogenetic and molecular lesions seen in the two disorders, there . . .
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Drs. Walter, Shen, and Ding contributed equally to this article
ISSN:0028-4793
1533-4406
1533-4406
DOI:10.1056/NEJMoa1106968