The roles of macrophage autophagy in atherosclerosis

Although various types of drugs and therapies are available to treat atherosclerosis, it remains a major cause of mortality throughout the world. Macrophages are the major source of foam cells, which are hallmarks of atherosclerotic lesions. Consequently, the roles of macrophages in the pathophysiol...

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Vydáno v:	Acta pharmacologica Sinica Ročník 37; číslo 2; s. 150 - 156
Hlavní autoři:	Shao, Bo-zong, Han, Bin-ze, Zeng, Yan-xia, Su, Ding-feng, Liu, Chong
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 01.02.2016 Nature Publishing Group
Témata:	Animals Atherosclerosis - complications Atherosclerosis - drug therapy Atherosclerosis - metabolism Atherosclerosis - pathology Autophagy - drug effects Biomedical and Life Sciences Biomedicine Cholesterol - metabolism Drug Discovery Humans Immunology Inflammation - complications Inflammation - metabolism Inflammation - pathology Internal Medicine Macrophages - drug effects Macrophages - metabolism Macrophages - pathology Medical Microbiology Molecular Targeted Therapy Pharmacology/Toxicology Review Signal Transduction - drug effects Vaccine 制剂处方药学药理 atherosclerosis macrophages autophagy cholesterol efflux
ISSN:	1671-4083, 1745-7254, 1745-7254
On-line přístup:	Získat plný text
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Popis
Shrnutí:	Although various types of drugs and therapies are available to treat atherosclerosis, it remains a major cause of mortality throughout the world. Macrophages are the major source of foam cells, which are hallmarks of atherosclerotic lesions. Consequently, the roles of macrophages in the pathophysiology of atherosclerosis are increasingly investigated. Autophagy is a self-protecting cellular catabolic pathway. Since its discovery, autophagy has been found to be associated with a variety of diseases, including cardiovascular diseases, malignant tumors, neurodegenerative diseases, and immune system disorders. Accumulating evidence demonstrates that autophagy plays an important role in inhibiting inflammation and apoptosis, and in promoting efferocytosis and cholesterol efflux. These facts sug- gest the induction of autophagy may be exploited as a potential strategy for the treatment of atherosclerosis. In this review we mainly discuss the relationship between macrophage autophagy and atherosclerosis and the molecular mechanisms, as well as the recent advances in targeting the process of autophagy to treat atherosclerosis.
Bibliografie:	macrophages; autophagy; atherosclerosis; cholesterol efflux Although various types of drugs and therapies are available to treat atherosclerosis, it remains a major cause of mortality throughout the world. Macrophages are the major source of foam cells, which are hallmarks of atherosclerotic lesions. Consequently, the roles of macrophages in the pathophysiology of atherosclerosis are increasingly investigated. Autophagy is a self-protecting cellular catabolic pathway. Since its discovery, autophagy has been found to be associated with a variety of diseases, including cardiovascular diseases, malignant tumors, neurodegenerative diseases, and immune system disorders. Accumulating evidence demonstrates that autophagy plays an important role in inhibiting inflammation and apoptosis, and in promoting efferocytosis and cholesterol efflux. These facts sug- gest the induction of autophagy may be exploited as a potential strategy for the treatment of atherosclerosis. In this review we mainly discuss the relationship between macrophage autophagy and atherosclerosis and the molecular mechanisms, as well as the recent advances in targeting the process of autophagy to treat atherosclerosis. 31-1347/R ObjectType-Article-1 SourceType-Scholarly Journals-1 content type line 14 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 These authors contributed equally to this work.
ISSN:	1671-4083 1745-7254 1745-7254
DOI:	10.1038/aps.2015.87