The roles of macrophage autophagy in atherosclerosis

Although various types of drugs and therapies are available to treat atherosclerosis, it remains a major cause of mortality throughout the world. Macrophages are the major source of foam cells, which are hallmarks of atherosclerotic lesions. Consequently, the roles of macrophages in the pathophysiol...

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Bibliographic Details
Published in:Acta pharmacologica Sinica Vol. 37; no. 2; pp. 150 - 156
Main Authors: Shao, Bo-zong, Han, Bin-ze, Zeng, Yan-xia, Su, Ding-feng, Liu, Chong
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 01.02.2016
Nature Publishing Group
Subjects:
Animals
Atherosclerosis - complications
Atherosclerosis - drug therapy
Atherosclerosis - metabolism
Atherosclerosis - pathology
Autophagy - drug effects
Biomedical and Life Sciences
Biomedicine
Cholesterol - metabolism
Drug Discovery
Humans
Immunology
Inflammation - complications
Inflammation - metabolism
Inflammation - pathology
Internal Medicine
Macrophages - drug effects
Macrophages - metabolism
Macrophages - pathology
Medical Microbiology
Molecular Targeted Therapy
Pharmacology/Toxicology
Review
Signal Transduction - drug effects
Vaccine
制剂
处方
药学
药理
atherosclerosis
macrophages
autophagy
cholesterol efflux
ISSN:1671-4083, 1745-7254, 1745-7254
Online Access:Get full text
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Summary:Although various types of drugs and therapies are available to treat atherosclerosis, it remains a major cause of mortality throughout the world. Macrophages are the major source of foam cells, which are hallmarks of atherosclerotic lesions. Consequently, the roles of macrophages in the pathophysiology of atherosclerosis are increasingly investigated. Autophagy is a self-protecting cellular catabolic pathway. Since its discovery, autophagy has been found to be associated with a variety of diseases, including cardiovascular diseases, malignant tumors, neurodegenerative diseases, and immune system disorders. Accumulating evidence demonstrates that autophagy plays an important role in inhibiting inflammation and apoptosis, and in promoting efferocytosis and cholesterol efflux. These facts sug- gest the induction of autophagy may be exploited as a potential strategy for the treatment of atherosclerosis. In this review we mainly discuss the relationship between macrophage autophagy and atherosclerosis and the molecular mechanisms, as well as the recent advances in targeting the process of autophagy to treat atherosclerosis.
Bibliography:macrophages; autophagy; atherosclerosis; cholesterol efflux
Although various types of drugs and therapies are available to treat atherosclerosis, it remains a major cause of mortality throughout the world. Macrophages are the major source of foam cells, which are hallmarks of atherosclerotic lesions. Consequently, the roles of macrophages in the pathophysiology of atherosclerosis are increasingly investigated. Autophagy is a self-protecting cellular catabolic pathway. Since its discovery, autophagy has been found to be associated with a variety of diseases, including cardiovascular diseases, malignant tumors, neurodegenerative diseases, and immune system disorders. Accumulating evidence demonstrates that autophagy plays an important role in inhibiting inflammation and apoptosis, and in promoting efferocytosis and cholesterol efflux. These facts sug- gest the induction of autophagy may be exploited as a potential strategy for the treatment of atherosclerosis. In this review we mainly discuss the relationship between macrophage autophagy and atherosclerosis and the molecular mechanisms, as well as the recent advances in targeting the process of autophagy to treat atherosclerosis.
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These authors contributed equally to this work.
ISSN:1671-4083
1745-7254
1745-7254
DOI:10.1038/aps.2015.87