Visual evoked potentials and MBP gene expression imply endogenous myelin repair in adult rat optic nerve and chiasm following local lysolecithin induced demyelination

Multiple sclerosis (MS) patients may suffer from optic disturbances. Toxin-induced demyelinations have frequently been developed to investigate the cellular and structural aspects of demyelination and remyelination processes, separately. The present study describes functional consequence of lysoleci...

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Bibliographic Details
Published in:	Brain research Vol. 1351; pp. 50 - 56
Main Authors:	Mozafari, Sabah, Sherafat, Mohammad Amin, Javan, Mohammad, Mirnajafi-Zadeh, Javad, Tiraihi, Taki
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier B.V 10.09.2010 Elsevier
Subjects:	Age Factors Animals Biological and medical sciences Demyelinating Diseases - chemically induced Demyelinating Diseases - metabolism Demyelinating Diseases - pathology Evoked Potentials, Visual - drug effects Evoked Potentials, Visual - physiology Eye and associated structures. Visual pathways and centers. Vision Female Fundamental and applied biological sciences. Psychology Gene Expression Regulation Lysophosphatidylcholines - toxicity Medical sciences Multiple sclerosis (MS) Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Myelin Basic Protein - biosynthesis Myelin Basic Protein - genetics Myelin repair Myelin Sheath - metabolism Myelin Sheath - pathology Neurology Optic Chiasm - drug effects Optic Chiasm - metabolism Optic Chiasm - pathology Optic Nerve - drug effects Optic Nerve - metabolism Optic Nerve - pathology Rat optic chiasm and nerves Rats Rats, Sprague-Dawley Transcription Factors - biosynthesis Transcription Factors - genetics Vertebrates: nervous system and sense organs Visual evoked potential (VEP) Myelin repair Visual evoked potential (VEP) Multiple sclerosis (MS) Rat optic chiasm and nerves Nervous system diseases Multiple sclerosis Optic nerve Rat Myelin Rodentia Electrophysiology Visual evoked potential Gene expression Optic chiasma Inflammatory disease Vertebrata Mammalia Visual pathway Demyelination Central nervous system disease Adult animal Repair
ISSN:	0006-8993, 1872-6240, 1872-6240
Online Access:	Get full text
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