Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria

ABSTRACT Background: PSP is a neuropathologically defined disease entity. Clinical diagnostic criteria, published in 1996 by the National Institute of Neurological Disorders and Stroke/Society for PSP, have excellent specificity, but their sensitivity is limited for variant PSP syndromes with presen...

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Vydané v:	Movement disorders Ročník 32; číslo 6; s. 853 - 864
Hlavní autori:	Höglinger, Günter U., Respondek, Gesine, Stamelou, Maria, Kurz, Carolin, Josephs, Keith A., Lang, Anthony E., Mollenhauer, Brit, Müller, Ulrich, Nilsson, Christer, Whitwell, Jennifer L., Arzberger, Thomas, Englund, Elisabet, Gelpi, Ellen, Giese, Armin, Irwin, David J., Meissner, Wassilios G., Pantelyat, Alexander, Rajput, Alex, Swieten, John C., Troakes, Claire, Antonini, Angelo, Bhatia, Kailash P., Bordelon, Yvette, Compta, Yaroslau, Corvol, Jean‐Christophe, Colosimo, Carlo, Dickson, Dennis W., Dodel, Richard, Ferguson, Leslie, Grossman, Murray, Kassubek, Jan, Krismer, Florian, Levin, Johannes, Lorenzl, Stefan, Morris, Huw R., Nestor, Peter, Oertel, Wolfgang H., Poewe, Werner, Rabinovici, Gil, Rowe, James B., Schellenberg, Gerard D., Seppi, Klaus, Eimeren, Thilo, Wenning, Gregor K., Boxer, Adam L., Golbe, Lawrence I., Litvan, Irene, Kurz, Caroline, van Swieten, John, van Eimeren, Thilo
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Wiley 01.06.2017
Predmet:	clinical diagnostic criteria Clinical Medicine consensus‐based evidence‐based Human health and pathology Humans Klinisk medicin Life Sciences Medical and Health Sciences Medicin och hälsovetenskap Neurologi Neurology Practice Guidelines as Topic - standards progressive supranuclear palsy Societies, Medical - standards Supranuclear Palsy, Progressive - diagnosis Supranuclear Palsy, Progressive - physiopathology clinical diagnostic criteria consensus-based evidence-based progressive supranuclear palsy
ISSN:	0885-3185, 1531-8257, 1531-8257
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Shrnutí:	ABSTRACT Background: PSP is a neuropathologically defined disease entity. Clinical diagnostic criteria, published in 1996 by the National Institute of Neurological Disorders and Stroke/Society for PSP, have excellent specificity, but their sensitivity is limited for variant PSP syndromes with presentations other than Richardson's syndrome. Objective: We aimed to provide an evidence‐ and consensus‐based revision of the clinical diagnostic criteria for PSP. Methods: We searched the PubMed, Cochrane, Medline, and PSYCInfo databases for articles published in English since 1996, using postmortem diagnosis or highly specific clinical criteria as the diagnostic standard. Second, we generated retrospective standardized clinical data from patients with autopsy‐confirmed PSP and control diseases. On this basis, diagnostic criteria were drafted, optimized in two modified Delphi evaluations, submitted to structured discussions with consensus procedures during a 2‐day meeting, and refined in three further Delphi rounds. Results: Defined clinical, imaging, laboratory, and genetic findings serve as mandatory basic features, mandatory exclusion criteria, or context‐dependent exclusion criteria. We identified four functional domains (ocular motor dysfunction, postural instability, akinesia, and cognitive dysfunction) as clinical predictors of PSP. Within each of these domains, we propose three clinical features that contribute different levels of diagnostic certainty. Specific combinations of these features define the diagnostic criteria, stratified by three degrees of diagnostic certainty (probable PSP, possible PSP, and suggestive of PSP). Clinical clues and imaging findings represent supportive features. Conclusions: Here, we present new criteria aimed to optimize early, sensitive, and specific clinical diagnosis of PSP on the basis of currently available evidence. © 2017 International Parkinson and Movement Disorder Society
Bibliografia:	Full financial disclosures and author roles may be found in the online version of this article. Nothing to report. Relevant conflicts of interest/financial disclosures Funding agencies The project was supported by the Bischof Dr. Karl Golser Stiftung, CurePSP, Deutsche Forschungsgemeinschaft (DFG, HO 2402/11‐1), German Center for Neurodegenerative Diseases e.V. (DZNE), German PSP Gesellschaft, Tau Consortium, UK PSP Association, and the International Parkinson and Movement Disorder Society. Drs. Höglinger, Respondek, Stamelou, Golbe, Boxer, and Litvan made an equal contribution. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 PMCID: PMC5516529 Drs. Hoglinger, Respondek, Stamelou, Golbe, Boxer, and Litvan made an equal contribution.
ISSN:	0885-3185 1531-8257 1531-8257
DOI:	10.1002/mds.26987