Vascular smooth muscle cell proliferation as a therapeutic target. Part 2: Natural products inhibiting proliferation

Many natural products have been so far tested regarding their potency to inhibit vascular smooth muscle cell proliferation, a process involved in atherosclerosis, pulmonary hypertension and restenosis. Compounds studied in vitro and in vivo as VSMC proliferation inhibitors include, for example indir...

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Veröffentlicht in:Biotechnology advances Jg. 36; H. 6; S. 1608 - 1621
Hauptverfasser: Uhrin, Pavel, Wang, Dongdong, Mocan, Andrei, Waltenberger, Birgit, Breuss, Johannes M., Tewari, Devesh, Mihaly-Bison, Judit, Huminiecki, Łukasz, Starzyński, Rafał R., Tzvetkov, Nikolay T., Horbańczuk, Jarosław, Atanasov, Atanas G.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England Elsevier Inc 01.11.2018
Elsevier Science Ltd
Schlagworte:
Atherosclerosis
Cancer
Cell growth
cell proliferation
Drug-discovery
Hypertension
Inhibitors
Molecular target
Muscles
Natural products
paclitaxel
pelargonidin
Rapamycin
Restenosis
resveratrol
Signaling pathway
smooth muscle
Taxol
therapeutics
Vascular endothelial growth factor
Vascular smooth muscle cell proliferation
Restenosis
Molecular target
Signaling pathway
Drug-discovery
Natural products
Atherosclerosis
Vascular smooth muscle cell proliferation
ISSN:0734-9750, 1873-1899, 1873-1899
Online-Zugang:Volltext
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Zusammenfassung:Many natural products have been so far tested regarding their potency to inhibit vascular smooth muscle cell proliferation, a process involved in atherosclerosis, pulmonary hypertension and restenosis. Compounds studied in vitro and in vivo as VSMC proliferation inhibitors include, for example indirubin-3′-monoxime, resveratrol, hyperoside, plumericin, pelargonidin, zerumbone and apamin. Moreover, taxol and rapamycin, the most prominent compounds applied in drug-eluting stents to counteract restenosis, are natural products. Numerous studies show that natural products have proven to yield effective inhibitors of vascular smooth muscle cell proliferation and ongoing research effort might result in the discovery of further clinically relevant compounds.
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ISSN:0734-9750
1873-1899
1873-1899
DOI:10.1016/j.biotechadv.2018.04.002