Vascular smooth muscle cell proliferation as a therapeutic target. Part 2: Natural products inhibiting proliferation

Many natural products have been so far tested regarding their potency to inhibit vascular smooth muscle cell proliferation, a process involved in atherosclerosis, pulmonary hypertension and restenosis. Compounds studied in vitro and in vivo as VSMC proliferation inhibitors include, for example indir...

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Podrobná bibliografia
Vydané v:	Biotechnology advances Ročník 36; číslo 6; s. 1608 - 1621
Hlavní autori:	Uhrin, Pavel, Wang, Dongdong, Mocan, Andrei, Waltenberger, Birgit, Breuss, Johannes M., Tewari, Devesh, Mihaly-Bison, Judit, Huminiecki, Łukasz, Starzyński, Rafał R., Tzvetkov, Nikolay T., Horbańczuk, Jarosław, Atanasov, Atanas G.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England Elsevier Inc 01.11.2018 Elsevier Science Ltd
Predmet:	Atherosclerosis Cancer Cell growth cell proliferation Drug-discovery Hypertension Inhibitors Molecular target Muscles Natural products paclitaxel pelargonidin Rapamycin Restenosis resveratrol Signaling pathway smooth muscle Taxol therapeutics Vascular endothelial growth factor Vascular smooth muscle cell proliferation Restenosis Molecular target Signaling pathway Drug-discovery Natural products Atherosclerosis Vascular smooth muscle cell proliferation
ISSN:	0734-9750, 1873-1899, 1873-1899
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Popis
Shrnutí:	Many natural products have been so far tested regarding their potency to inhibit vascular smooth muscle cell proliferation, a process involved in atherosclerosis, pulmonary hypertension and restenosis. Compounds studied in vitro and in vivo as VSMC proliferation inhibitors include, for example indirubin-3′-monoxime, resveratrol, hyperoside, plumericin, pelargonidin, zerumbone and apamin. Moreover, taxol and rapamycin, the most prominent compounds applied in drug-eluting stents to counteract restenosis, are natural products. Numerous studies show that natural products have proven to yield effective inhibitors of vascular smooth muscle cell proliferation and ongoing research effort might result in the discovery of further clinically relevant compounds.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23
ISSN:	0734-9750 1873-1899 1873-1899
DOI:	10.1016/j.biotechadv.2018.04.002