NP body domain and PB2 contribute to increased virulence of H5N1 highly pathogenic avian influenza viruses in chickens

The molecular basis of pathogenicity of H5N1 highly pathogenic avian influenza (HPAI) viruses in chickens remains largely unknown. H5N1 A/chicken/Yamaguchi/7/2004 virus (CkYM7) replicates rapidly in macrophages and vascular endothelial cells in chickens, causing sudden death without fever or gross l...

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Bibliographic Details
Published in:	Journal of virology Vol. 85; no. 4; p. 1834
Main Authors:	Tada, Tatsuya, Suzuki, Koutaro, Sakurai, Yu, Kubo, Masanori, Okada, Hironao, Itoh, Toshihiro, Tsukamoto, Kenji
Format:	Journal Article
Language:	English
Published:	United States 15.02.2011
Subjects:	Amino Acid Sequence Animals Cell Line Chick Embryo Chickens - virology Ducks - virology Fibroblasts - virology Humans Influenza A Virus, H5N1 Subtype - classification Influenza A Virus, H5N1 Subtype - genetics Influenza A Virus, H5N1 Subtype - metabolism Influenza A Virus, H5N1 Subtype - pathogenicity Influenza in Birds - pathology Influenza in Birds - virology Reassortant Viruses - genetics Reassortant Viruses - metabolism Reassortant Viruses - pathogenicity RNA Replicase - chemistry RNA Replicase - genetics RNA Replicase - metabolism RNA-Binding Proteins - chemistry RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Specific Pathogen-Free Organisms Viral Core Proteins - chemistry Viral Core Proteins - genetics Viral Core Proteins - metabolism Viral Proteins - chemistry Viral Proteins - genetics Viral Proteins - metabolism Virulence Virus Replication
ISSN:	1098-5514, 1098-5514
Online Access:	Get more information
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