A systematic review of nutritional risk factors of Parkinson's disease

A wide variety of nutritional exposures have been proposed as possible risk factors for Parkinson's disease (PD) with plausible biological hypotheses. Many studies have explored these hypotheses, but as yet no comprehensive systematic review of the literature has been available. MEDLINE, EMBASE...

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Bibliographic Details
Published in:Nutrition research reviews Vol. 18; no. 2; pp. 259 - 282
Main Authors: Ishihara, Lianna, Brayne, Carol
Format: Journal Article
Language:English
Published: Cambridge, UK Cambridge University Press 01.12.2005
Subjects:
antioxidants
Biological and medical sciences
Caffeine
Carbohydrates
Coffee
Dairy products
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
dietary minerals
literature reviews
Medical sciences
meta-analysis
Neurology
nutrition
Parkinson disease
Parkinson's disease
Risk factors
Systematic review
Parkinson's disease
Antioxidant risk
Nutrition
Human
Nervous system diseases
Parkinson disease
Review
Antioxidant
Parkinson's disease: Nutrition: Systematic review: Antioxidant risk
Cerebral disorder
Feeding
Central nervous system disease
Risk factor
Degenerative disease
Extrapyramidal syndrome
ISSN:0954-4224, 1475-2700, 1475-2700
Online Access:Get full text
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Summary:A wide variety of nutritional exposures have been proposed as possible risk factors for Parkinson's disease (PD) with plausible biological hypotheses. Many studies have explored these hypotheses, but as yet no comprehensive systematic review of the literature has been available. MEDLINE, EMBASE, and WEB OF SCIENCE databases were searched for existing systematic reviews or meta-analyses of nutrition and PD, and one meta-analysis of coffee drinking and one meta-analysis of antioxidants were identified. The databases were searched for primary research articles, and articles without robust methodology were excluded by specified criteria. Seven cohort studies and thirty-three case–control (CC) studies are included in the present systematic review. The majority of studies did not find significant associations between nutritional factors and PD. Coffee drinking and alcohol intake were the only exposures with a relatively large number of studies, and meta-analyses of each supported inverse associations with PD. Factors that were reported by at least one CC study to have significantly increased consumption among cases compared with controls were: vegetables, lutein, xanthophylls, xanthins, carbohydrates, monosaccharides, junk food, refined sugar, lactose, animal fat, total fat, nuts and seeds, tea, Fe, and total energy. Factors consumed significantly less often among cases were: fish, egg, potatoes, bread, alcohol, coffee, tea, niacin, pantothenic acid, folate and pyridoxine. In three cohort studies, two reported borderline decreased relative risks and one a significant increased risk with vitamin C intake. One cohort reported an inverse association between caffeine intake and PD. Three cohorts reported significant positive association in men between dairy products and PD.
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ISSN:0954-4224
1475-2700
1475-2700
DOI:10.1079/NRR2005108