Evolutionary classification of CRISPR-Cas systems: a burst of class 2 and derived variants

The number and diversity of known CRISPR-Cas systems have substantially increased in recent years. Here, we provide an updated evolutionary classification of CRISPR-Cas systems and cas genes, with an emphasis on the major developments that have occurred since the publication of the latest classifica...

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Bibliographic Details
Published in:	Nature reviews. Microbiology Vol. 18; no. 2; pp. 67 - 83
Main Authors:	Makarova, Kira S, Wolf, Yuri I, Iranzo, Jaime, Shmakov, Sergey A, Alkhnbashi, Omer S, Brouns, Stan J J, Charpentier, Emmanuelle, Cheng, David, Haft, Daniel H, Horvath, Philippe, Moineau, Sylvain, Mojica, Francisco J M, Scott, David, Shah, Shiraz A, Siksnys, Virginijus, Terns, Michael P, Venclovas, Česlovas, White, Malcolm F, Yakunin, Alexander F, Yan, Winston, Zhang, Feng, Garrett, Roger A, Backofen, Rolf, van der Oost, John, Barrangou, Rodolphe, Koonin, Eugene V
Format:	Journal Article
Language:	English
Published:	England Nature Publishing Group 01.02.2020
Subjects:	Adaptive immunity Archaea - genetics Bacteria - genetics Biological evolution Classification CRISPR CRISPR-Cas Systems - genetics CRISPR-Cas Systems - physiology Evolution, Molecular Evolutionary genetics Gene Expression Regulation, Archaeal - physiology Gene Expression Regulation, Bacterial - physiology Genes Nuclease Ribonucleic acid RNA Signal transduction Transposition
ISSN:	1740-1526, 1740-1534, 1740-1534
Online Access:	Get full text
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