Evolutionary classification of CRISPR-Cas systems: a burst of class 2 and derived variants
The number and diversity of known CRISPR-Cas systems have substantially increased in recent years. Here, we provide an updated evolutionary classification of CRISPR-Cas systems and cas genes, with an emphasis on the major developments that have occurred since the publication of the latest classifica...
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| Vydané v: | Nature reviews. Microbiology Ročník 18; číslo 2; s. 67 - 83 |
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| Hlavní autori: | , , , , , , , , , , , , , , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
| Vydavateľské údaje: |
England
Nature Publishing Group
01.02.2020
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| ISSN: | 1740-1526, 1740-1534, 1740-1534 |
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| Abstract | The number and diversity of known CRISPR-Cas systems have substantially increased in recent years. Here, we provide an updated evolutionary classification of CRISPR-Cas systems and cas genes, with an emphasis on the major developments that have occurred since the publication of the latest classification, in 2015. The new classification includes 2 classes, 6 types and 33 subtypes, compared with 5 types and 16 subtypes in 2015. A key development is the ongoing discovery of multiple, novel class 2 CRISPR-Cas systems, which now include 3 types and 17 subtypes. A second major novelty is the discovery of numerous derived CRISPR-Cas variants, often associated with mobile genetic elements that lack the nucleases required for interference. Some of these variants are involved in RNA-guided transposition, whereas others are predicted to perform functions distinct from adaptive immunity that remain to be characterized experimentally. The third highlight is the discovery of numerous families of ancillary CRISPR-linked genes, often implicated in signal transduction. Together, these findings substantially clarify the functional diversity and evolutionary history of CRISPR-Cas. |
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| AbstractList | The number and diversity of known CRISPR-Cas systems have substantially increased in recent years. Here, we provide an updated evolutionary classification of CRISPR-Cas systems and cas genes, with an emphasis on the major developments that have occurred since the publication of the latest classification, in 2015. The new classification includes 2 classes, 6 types and 33 subtypes, compared with 5 types and 16 subtypes in 2015. A key development is the ongoing discovery of multiple, novel class 2 CRISPR-Cas systems, which now include 3 types and 17 subtypes. A second major novelty is the discovery of numerous derived CRISPR-Cas variants, often associated with mobile genetic elements that lack the nucleases required for interference. Some of these variants are involved in RNA-guided transposition, whereas others are predicted to perform functions distinct from adaptive immunity that remain to be characterized experimentally. The third highlight is the discovery of numerous families of ancillary CRISPR-linked genes, often implicated in signal transduction. Together, these findings substantially clarify the functional diversity and evolutionary history of CRISPR-Cas. The number and diversity of known CRISPR–Cas systems have substantially increased in recent years. Here, we provide an updated evolutionary classification of CRISPR–Cas systems and cas genes, with an emphasis on the major developments that have occurred since the publication of the latest classification, in 2015. The new classification includes 2 classes, 6 types and 33 subtypes, compared with 5 types and 16 subtypes in 2015. A key development is the ongoing discovery of multiple, novel class 2 CRISPR–Cas systems, which now include 3 types and 17 subtypes. A second major novelty is the discovery of numerous derived CRISPR–Cas variants, often associated with mobile genetic elements that lack the nucleases required for interference. Some of these variants are involved in RNA-guided transposition, whereas others are predicted to perform functions distinct from adaptive immunity that remain to be characterized experimentally. The third highlight is the discovery of numerous families of ancillary CRISPR-linked genes, often implicated in signal transduction. Together, these findings substantially clarify the functional diversity and evolutionary history of CRISPR–Cas.The number and diversity of known CRISPR–Cas systems have substantially increased in recent years. In this Review, Koonin and colleagues provide an updated evolutionary classification of CRISPR–Cas systems and cas genes, with an emphasis on major developments, and outline a complete scenario for the origins and evolution of CRISPR–Cas systems. The number and diversity of known CRISPR-Cas systems have substantially increased in recent years. Here, we provide an updated evolutionary classification of CRISPR-Cas systems and cas genes, with an emphasis on the major developments that have occurred since the publication of the latest classification, in 2015. The new classification includes 2 classes, 6 types and 33 subtypes, compared with 5 types and 16 subtypes in 2015. A key development is the ongoing discovery of multiple, novel class 2 CRISPR-Cas systems, which now include 3 types and 17 subtypes. A second major novelty is the discovery of numerous derived CRISPR-Cas variants, often associated with mobile genetic elements that lack the nucleases required for interference. Some of these variants are involved in RNA-guided transposition, whereas others are predicted to perform functions distinct from adaptive immunity that remain to be characterized experimentally. The third highlight is the discovery of numerous families of ancillary CRISPR-linked genes, often implicated in signal transduction. Together, these findings substantially clarify the functional diversity and evolutionary history of CRISPR-Cas.The number and diversity of known CRISPR-Cas systems have substantially increased in recent years. Here, we provide an updated evolutionary classification of CRISPR-Cas systems and cas genes, with an emphasis on the major developments that have occurred since the publication of the latest classification, in 2015. The new classification includes 2 classes, 6 types and 33 subtypes, compared with 5 types and 16 subtypes in 2015. A key development is the ongoing discovery of multiple, novel class 2 CRISPR-Cas systems, which now include 3 types and 17 subtypes. A second major novelty is the discovery of numerous derived CRISPR-Cas variants, often associated with mobile genetic elements that lack the nucleases required for interference. Some of these variants are involved in RNA-guided transposition, whereas others are predicted to perform functions distinct from adaptive immunity that remain to be characterized experimentally. The third highlight is the discovery of numerous families of ancillary CRISPR-linked genes, often implicated in signal transduction. Together, these findings substantially clarify the functional diversity and evolutionary history of CRISPR-Cas. |
| Author | Brouns, Stan J J Koonin, Eugene V Scott, David Siksnys, Virginijus White, Malcolm F Barrangou, Rodolphe Yakunin, Alexander F Wolf, Yuri I van der Oost, John Iranzo, Jaime Alkhnbashi, Omer S Mojica, Francisco J M Yan, Winston Haft, Daniel H Makarova, Kira S Zhang, Feng Garrett, Roger A Charpentier, Emmanuelle Backofen, Rolf Horvath, Philippe Moineau, Sylvain Shah, Shiraz A Cheng, David Terns, Michael P Shmakov, Sergey A Venclovas, Česlovas |
| Author_xml | – sequence: 1 givenname: Kira S orcidid: 0000-0002-8174-2844 surname: Makarova fullname: Makarova, Kira S organization: National Center for Biotechnology Information, National Library of Medicine, Bethesda, MD, USA – sequence: 2 givenname: Yuri I orcidid: 0000-0002-0247-8708 surname: Wolf fullname: Wolf, Yuri I organization: National Center for Biotechnology Information, National Library of Medicine, Bethesda, MD, USA – sequence: 3 givenname: Jaime surname: Iranzo fullname: Iranzo, Jaime organization: National Center for Biotechnology Information, National Library of Medicine, Bethesda, MD, USA – sequence: 4 givenname: Sergey A surname: Shmakov fullname: Shmakov, Sergey A organization: National Center for Biotechnology Information, National Library of Medicine, Bethesda, MD, USA – sequence: 5 givenname: Omer S surname: Alkhnbashi fullname: Alkhnbashi, Omer S organization: Bioinformatics group, Department of Computer Science, University of Freiberg, Freiberg, Germany – sequence: 6 givenname: Stan J J surname: Brouns fullname: Brouns, Stan J J organization: Kavli Institute of Nanoscience, Department of Bionanoscience, Delft University of Technology, Delft, The Netherlands – sequence: 7 givenname: Emmanuelle surname: Charpentier fullname: Charpentier, Emmanuelle organization: Max Planck Unit for the Science of Pathogens, Humboldt University, Berlin, Germany – sequence: 8 givenname: David surname: Cheng fullname: Cheng, David organization: Arbor Biotechnologies, Cambridge, MA, USA – sequence: 9 givenname: Daniel H surname: Haft fullname: Haft, Daniel H organization: National Center for Biotechnology Information, National Library of Medicine, Bethesda, MD, USA – sequence: 10 givenname: Philippe surname: Horvath fullname: Horvath, Philippe organization: DuPont Nutrition and Health, Dangé-Saint-Romain, France – sequence: 11 givenname: Sylvain orcidid: 0000-0002-2832-5101 surname: Moineau fullname: Moineau, Sylvain organization: Département de biochimie, de microbiologie et de bio-informatique, Faculté des sciences et de génie, Groupe de recherche en écologie buccale, Félix d'Hérelle Reference Center for Bacterial Viruses, Faculté de médecine dentaire, Université Laval, Québec City, Québec, Canada – sequence: 12 givenname: Francisco J M orcidid: 0000-0002-6660-4996 surname: Mojica fullname: Mojica, Francisco J M organization: Departamento de Fisiología, Genética y Microbiología, Universidad de Alicante, Alicante, Spain – sequence: 13 givenname: David surname: Scott fullname: Scott, David organization: Arbor Biotechnologies, Cambridge, MA, USA – sequence: 14 givenname: Shiraz A surname: Shah fullname: Shah, Shiraz A organization: COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Gentofte, Denmark – sequence: 15 givenname: Virginijus surname: Siksnys fullname: Siksnys, Virginijus organization: Institute of Biotechnology, Life Sciences Center, Vilnius University, Vilnius, Lithuania – sequence: 16 givenname: Michael P surname: Terns fullname: Terns, Michael P organization: Biochemistry and Molecular Biology, Genetics and Microbiology, University of Georgia, Athens, GA, USA – sequence: 17 givenname: Česlovas orcidid: 0000-0002-4215-0213 surname: Venclovas fullname: Venclovas, Česlovas organization: Institute of Biotechnology, Life Sciences Center, Vilnius University, Vilnius, Lithuania – sequence: 18 givenname: Malcolm F orcidid: 0000-0003-1543-9342 surname: White fullname: White, Malcolm F organization: Biomedical Sciences Research Complex, University of St. Andrews, St. Andrews, UK – sequence: 19 givenname: Alexander F orcidid: 0000-0003-0813-6490 surname: Yakunin fullname: Yakunin, Alexander F organization: Centre for Environmental Biotechnology, School of Natural Sciences, Bangor University, Bangor, Gwynedd, UK – sequence: 20 givenname: Winston surname: Yan fullname: Yan, Winston organization: Arbor Biotechnologies, Cambridge, MA, USA – sequence: 21 givenname: Feng surname: Zhang fullname: Zhang, Feng organization: Department of Brain and Cognitive Sciences and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA – sequence: 22 givenname: Roger A surname: Garrett fullname: Garrett, Roger A organization: Archaea Centre, Department of Biology, Copenhagen University, Copenhagen, Denmark – sequence: 23 givenname: Rolf surname: Backofen fullname: Backofen, Rolf organization: BIOSS Centre for Biological Signaling Studies, Cluster of Excellence, University of Freiburg, Freiburg, Germany – sequence: 24 givenname: John orcidid: 0000-0001-5024-1871 surname: van der Oost fullname: van der Oost, John organization: Laboratory of Microbiology, Wageningen University, Wageningen, The Netherlands – sequence: 25 givenname: Rodolphe orcidid: 0000-0002-0648-3504 surname: Barrangou fullname: Barrangou, Rodolphe organization: Department of Food, Bioprocessing, and Nutrition Sciences, North Carolina State University, Raleigh, NC, USA – sequence: 26 givenname: Eugene V orcidid: 0000-0003-3943-8299 surname: Koonin fullname: Koonin, Eugene V email: koonin@ncbi.nlm.nih.gov organization: National Center for Biotechnology Information, National Library of Medicine, Bethesda, MD, USA. koonin@ncbi.nlm.nih.gov |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31857715$$D View this record in MEDLINE/PubMed |
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| ContentType | Journal Article |
| Copyright | 2019© This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2019 |
| Copyright_xml | – notice: 2019© This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2019 |
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| DOI | 10.1038/s41579-019-0299-x |
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| Snippet | The number and diversity of known CRISPR-Cas systems have substantially increased in recent years. Here, we provide an updated evolutionary classification of... The number and diversity of known CRISPR–Cas systems have substantially increased in recent years. Here, we provide an updated evolutionary classification of... |
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| SubjectTerms | Adaptive immunity Archaea - genetics Bacteria - genetics Biological evolution Classification CRISPR CRISPR-Cas Systems - genetics CRISPR-Cas Systems - physiology Evolution, Molecular Evolutionary genetics Gene Expression Regulation, Archaeal - physiology Gene Expression Regulation, Bacterial - physiology Genes Nuclease Ribonucleic acid RNA Signal transduction Transposition |
| Title | Evolutionary classification of CRISPR-Cas systems: a burst of class 2 and derived variants |
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