Defining a healthy human gut microbiome: current concepts, future directions, and clinical applications

Indigenous microbiota are an essential component in the modern concept of human health, but the composition and functional characteristics of a healthy microbiome remain to be precisely defined. Patterns of microbial colonization associated with disease states have been documented, but the health-as...

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Vydané v:Cell host & microbe Ročník 12; číslo 5; s. 611
Hlavní autori: Bäckhed, Fredrik, Fraser, Claire M, Ringel, Yehuda, Sanders, Mary Ellen, Sartor, R Balfour, Sherman, Philip M, Versalovic, James, Young, Vincent, Finlay, B Brett
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States 15.11.2012
Predmet:
Anti-Bacterial Agents
Gastrointestinal Tract - microbiology
Humans
Intestinal Diseases - microbiology
Metagenome
Microbial Consortia
Prebiotics
Probiotics
ISSN:1934-6069, 1934-6069
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Shrnutí:Indigenous microbiota are an essential component in the modern concept of human health, but the composition and functional characteristics of a healthy microbiome remain to be precisely defined. Patterns of microbial colonization associated with disease states have been documented, but the health-associated microbial patterns and their functional characteristics are less clear. A healthy microbiome, considered in the context of body habitat or body site, could be described in terms of ecologic stability (i.e., ability to resist community structure change under stress or to rapidly return to baseline following a stress-related change), by an idealized (presumably health-associated) composition or by a desirable functional profile (including metabolic and trophic provisions to the host). Elucidation of the properties of healthy microbiota would provide a target for dietary interventions and/or microbial modifications aimed at sustaining health in generally healthy populations and improving the health of individuals exhibiting disrupted microbiota and associated diseases.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1934-6069
1934-6069
DOI:10.1016/j.chom.2012.10.012