Increased mortality among people with anxiety disorders: total population study

Anxiety disorders and depression are the most common mental disorders worldwide and have a striking impact on global disease burden. Although depression has consistently been found to increase mortality; the role of anxiety disorders in predicting mortality risk is unclear. To assess mortality risk...

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Published in:British journal of psychiatry Vol. 209; no. 3; pp. 216 - 221
Main Authors: Meier, Sandra M., Mattheisen, Manuel, Mors, Ole, Mortensen, Preben B., Laursen, Thomas M., Penninx, Brenda W.
Format: Journal Article
Language:English
Published: Cambridge, UK Cambridge University Press 01.09.2016
Subjects:
Adult
Anxiety
Anxiety disorders
Anxiety Disorders - epidemiology
Anxiety Disorders - mortality
Case-Control Studies
Cause of Death
Cohort analysis
Comorbidity
Denmark - epidemiology
Depression - epidemiology
Depression - mortality
Disorders
Female
Health risk assessment
Humans
Male
Mental depression
Mental disorders
Middle Aged
Mortality
Mortality rates
Population studies
Population-based studies
Psychiatry
Registries
Risk
Risk assessment
Systematic review
Young Adult
Denmark
Aarhus Denmark
ISSN:0007-1250, 1472-1465, 1472-1465
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Abstract Anxiety disorders and depression are the most common mental disorders worldwide and have a striking impact on global disease burden. Although depression has consistently been found to increase mortality; the role of anxiety disorders in predicting mortality risk is unclear. To assess mortality risk in people with anxiety disorders. We used nationwide Danish register data to conduct a prospective cohort study with over 30 million person-years of follow-up. In total, 1066 (2.1%) people with anxiety disorders died during an average follow-up of 9.7 years. The risk of death by natural and unnatural causes was significantly higher among individuals with anxiety disorders (natural mortality rate ratio (MRR) = 1.39, 95% CI 1.28-1.51; unnatural MRR = 2.46, 95% CI 2.20-2.73) compared with the general population. Of those who died from unnatural causes, 16.5% had comorbid diagnoses of depression (MRR = 11.72, 95% CI 10.11-13.51). Anxiety disorders significantly increased mortality risk. Comorbidity of anxiety disorders and depression played an important part in the increased mortality.
AbstractList Anxiety disorders and depression are the most common mental disorders worldwide and have a striking impact on global disease burden. Although depression has consistently been found to increase mortality; the role of anxiety disorders in predicting mortality risk is unclear. To assess mortality risk in people with anxiety disorders. We used nationwide Danish register data to conduct a prospective cohort study with over 30 million person-years of follow-up. In total, 1066 (2.1%) people with anxiety disorders died during an average follow-up of 9.7 years. The risk of death by natural and unnatural causes was significantly higher among individuals with anxiety disorders (natural mortality rate ratio (MRR) = 1.39, 95% CI 1.28-1.51; unnatural MRR = 2.46, 95% CI 2.20-2.73) compared with the general population. Of those who died from unnatural causes, 16.5% had comorbid diagnoses of depression (MRR = 11.72, 95% CI 10.11-13.51). Anxiety disorders significantly increased mortality risk. Comorbidity of anxiety disorders and depression played an important part in the increased mortality.
Background Anxiety disorders and depression are the most common mental disorders worldwide and have a striking impact on global disease burden. Although depression has consistently been found to increase mortality; the role of anxiety disorders in predicting mortality risk is unclear. Aims To assess mortality risk in people with anxiety disorders. Method We used nationwide Danish register data to conduct a prospective cohort study with over 30 million person-years of follow-up. Results In total, 1066 (2.1%) people with anxiety disorders died during an average follow-up of 9.7 years. The risk of death by natural and unnatural causes was significantly higher among individuals with anxiety disorders (natural mortality rate ratio (MRR) = 1.39, 95% CI 1.28-1.51; unnatural MRR = 2.46, 95% CI 2.20-2.73) compared with the general population. Of those who died from unnatural causes, 16.5% had comorbid diagnoses of depression (MRR = 11.72, 95% CI 10.11-13.51). Conclusions Anxiety disorders significantly increased mortality risk. Comorbidity of anxiety disorders and depression played an important part in the increased mortality.
BackgroundAnxiety disorders and depression are the most common mental disorders worldwide and have a striking impact on global disease burden. Although depression has consistently been found to increase mortality; the role of anxiety disorders in predicting mortality risk is unclear.AimsTo assess mortality risk in people with anxiety disorders.MethodWe used nationwide Danish register data to conduct a prospective cohort study with over 30 million person-years of follow-up.ResultsIn total, 1066 (2.1%) people with anxiety disorders died during an average follow-up of 9.7 years. The risk of death by natural and unnatural causes was significantly higher among individuals with anxiety disorders (natural mortality rate ratio (MRR) = 1.39, 95% CI 1.28–1.51; unnatural MRR= 2.46, 95% CI 2.20–2.73) compared with the general population. Of those who died from unnatural causes, 16.5% had comorbid diagnoses of depression (MRR = 11.72, 95% CI 10.11–13.51).ConclusionsAnxiety disorders significantly increased mortality risk. Comorbidity of anxiety disorders and depression played an important part in the increased mortality.
Anxiety disorders and depression are the most common mental disorders worldwide and have a striking impact on global disease burden. Although depression has consistently been found to increase mortality; the role of anxiety disorders in predicting mortality risk is unclear.BACKGROUNDAnxiety disorders and depression are the most common mental disorders worldwide and have a striking impact on global disease burden. Although depression has consistently been found to increase mortality; the role of anxiety disorders in predicting mortality risk is unclear.To assess mortality risk in people with anxiety disorders.AIMSTo assess mortality risk in people with anxiety disorders.We used nationwide Danish register data to conduct a prospective cohort study with over 30 million person-years of follow-up.METHODWe used nationwide Danish register data to conduct a prospective cohort study with over 30 million person-years of follow-up.In total, 1066 (2.1%) people with anxiety disorders died during an average follow-up of 9.7 years. The risk of death by natural and unnatural causes was significantly higher among individuals with anxiety disorders (natural mortality rate ratio (MRR) = 1.39, 95% CI 1.28-1.51; unnatural MRR = 2.46, 95% CI 2.20-2.73) compared with the general population. Of those who died from unnatural causes, 16.5% had comorbid diagnoses of depression (MRR = 11.72, 95% CI 10.11-13.51).RESULTSIn total, 1066 (2.1%) people with anxiety disorders died during an average follow-up of 9.7 years. The risk of death by natural and unnatural causes was significantly higher among individuals with anxiety disorders (natural mortality rate ratio (MRR) = 1.39, 95% CI 1.28-1.51; unnatural MRR = 2.46, 95% CI 2.20-2.73) compared with the general population. Of those who died from unnatural causes, 16.5% had comorbid diagnoses of depression (MRR = 11.72, 95% CI 10.11-13.51).Anxiety disorders significantly increased mortality risk. Comorbidity of anxiety disorders and depression played an important part in the increased mortality.CONCLUSIONSAnxiety disorders significantly increased mortality risk. Comorbidity of anxiety disorders and depression played an important part in the increased mortality.
Author Mortensen, Preben B.
Laursen, Thomas M.
Mattheisen, Manuel
Meier, Sandra M.
Mors, Ole
Penninx, Brenda W.
Author_xml – sequence: 1
  givenname: Sandra M.
  surname: Meier
  fullname: Meier, Sandra M.
  email: smeier@econ.au.dk
  organization: National Centre for Register-Based Research, Aarhus University, Aarhus, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, and Mental Health Centre for Child and Adolescent Psychiatry, Copenhagen Region, Denmark
– sequence: 2
  givenname: Manuel
  surname: Mattheisen
  fullname: Mattheisen, Manuel
  organization: The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, and Department of Biomedicine, Aarhus University, Aarhus, Denmark
– sequence: 3
  givenname: Ole
  surname: Mors
  fullname: Mors, Ole
  organization: The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, and Research Department P, Aarhus University Hospital, Risskov, Denmark
– sequence: 4
  givenname: Preben B.
  surname: Mortensen
  fullname: Mortensen, Preben B.
  organization: National Centre for Register-Based Research, Aarhus University, Aarhus, and The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark
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  givenname: Thomas M.
  surname: Laursen
  fullname: Laursen, Thomas M.
  organization: National Centre for Register-Based Research, Aarhus University, Aarhus, and The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark
– sequence: 6
  givenname: Brenda W.
  surname: Penninx
  fullname: Penninx, Brenda W.
  organization: Department of Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, Netherlands
BackLink https://www.ncbi.nlm.nih.gov/pubmed/27388572$$D View this record in MEDLINE/PubMed
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The Royal College of Psychiatrists 2016.
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Snippet Anxiety disorders and depression are the most common mental disorders worldwide and have a striking impact on global disease burden. Although depression has...
BackgroundAnxiety disorders and depression are the most common mental disorders worldwide and have a striking impact on global disease burden. Although...
Background Anxiety disorders and depression are the most common mental disorders worldwide and have a striking impact on global disease burden. Although...
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StartPage 216
SubjectTerms Adult
Anxiety
Anxiety disorders
Anxiety Disorders - epidemiology
Anxiety Disorders - mortality
Case-Control Studies
Cause of Death
Cohort analysis
Comorbidity
Denmark - epidemiology
Depression - epidemiology
Depression - mortality
Disorders
Female
Health risk assessment
Humans
Male
Mental depression
Mental disorders
Middle Aged
Mortality
Mortality rates
Population studies
Population-based studies
Psychiatry
Registries
Risk
Risk assessment
Systematic review
Young Adult
Title Increased mortality among people with anxiety disorders: total population study
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https://www.ncbi.nlm.nih.gov/pubmed/27388572
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https://pubmed.ncbi.nlm.nih.gov/PMC5082973
Volume 209
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