Increased mortality among people with anxiety disorders: total population study

Anxiety disorders and depression are the most common mental disorders worldwide and have a striking impact on global disease burden. Although depression has consistently been found to increase mortality; the role of anxiety disorders in predicting mortality risk is unclear. To assess mortality risk...

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Bibliographic Details
Published in:British journal of psychiatry Vol. 209; no. 3; pp. 216 - 221
Main Authors: Meier, Sandra M., Mattheisen, Manuel, Mors, Ole, Mortensen, Preben B., Laursen, Thomas M., Penninx, Brenda W.
Format: Journal Article
Language:English
Published: Cambridge, UK Cambridge University Press 01.09.2016
Subjects:
Adult
Anxiety
Anxiety disorders
Anxiety Disorders - epidemiology
Anxiety Disorders - mortality
Case-Control Studies
Cause of Death
Cohort analysis
Comorbidity
Denmark - epidemiology
Depression - epidemiology
Depression - mortality
Disorders
Female
Health risk assessment
Humans
Male
Mental depression
Mental disorders
Middle Aged
Mortality
Mortality rates
Population studies
Population-based studies
Psychiatry
Registries
Risk
Risk assessment
Systematic review
Young Adult
Denmark
Aarhus Denmark
ISSN:0007-1250, 1472-1465, 1472-1465
Online Access:Get full text
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Summary:Anxiety disorders and depression are the most common mental disorders worldwide and have a striking impact on global disease burden. Although depression has consistently been found to increase mortality; the role of anxiety disorders in predicting mortality risk is unclear. To assess mortality risk in people with anxiety disorders. We used nationwide Danish register data to conduct a prospective cohort study with over 30 million person-years of follow-up. In total, 1066 (2.1%) people with anxiety disorders died during an average follow-up of 9.7 years. The risk of death by natural and unnatural causes was significantly higher among individuals with anxiety disorders (natural mortality rate ratio (MRR) = 1.39, 95% CI 1.28-1.51; unnatural MRR = 2.46, 95% CI 2.20-2.73) compared with the general population. Of those who died from unnatural causes, 16.5% had comorbid diagnoses of depression (MRR = 11.72, 95% CI 10.11-13.51). Anxiety disorders significantly increased mortality risk. Comorbidity of anxiety disorders and depression played an important part in the increased mortality.
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ISSN:0007-1250
1472-1465
1472-1465
DOI:10.1192/bjp.bp.115.171975