Combination of nitric oxide and drug delivery systems: tools for overcoming drug resistance in chemotherapy

Chemotherapeutic drugs have made significant contributions to anticancer therapy, along with other therapeutic methods including surgery and radiotherapy over the past century. However, multidrug resistance (MDR) of cancer cells has remained as a significant obstacle in the achievement of efficient...

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Bibliographic Details
Published in:Journal of controlled release Vol. 263; pp. 223 - 230
Main Authors: Kim, Jihoon, Yung, Bryant C., Kim, Won Jong, Chen, Xiaoyuan
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 10.10.2017
Subjects:
adverse effects
Animals
antineoplastic agents
Antineoplastic Agents - administration & dosage
Cancer
Chemosensitization
Drug Delivery Systems
Drug Resistance, Neoplasm - drug effects
drug therapy
Humans
Multidrug resistance (MDR)
multiple drug resistance
Nanoparticle
neoplasm cells
neoplasms
Neoplasms - drug therapy
Neoplasms - metabolism
nitric oxide
Nitric oxide (NO) donor
Nitric Oxide - metabolism
Nitric Oxide Donors - administration & dosage
radiotherapy
surgery
toxicity
Nitric oxide (NO) donor
Multidrug resistance (MDR)
Chemosensitization
Nanoparticle
Cancer
ISSN:0168-3659, 1873-4995, 1873-4995
Online Access:Get full text
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Summary:Chemotherapeutic drugs have made significant contributions to anticancer therapy, along with other therapeutic methods including surgery and radiotherapy over the past century. However, multidrug resistance (MDR) of cancer cells has remained as a significant obstacle in the achievement of efficient chemotherapy. Recently, there has been increasing evidence for the potential function of nitric oxide (NO) to overcome MDR. NO is an endogenous and biocompatible molecule, contrasting with other potentially toxic chemosensitizing agents that reverse MDR effects, which has raised expectations in the development of efficient therapeutics with low side effects. In particular, nanoparticle-based drug delivery systems not only facilitate the delivery of multiple therapeutic agents, but also help bypass MDR pathways, which are conducive for the efficient delivery of NO and anticancer drugs, simultaneously. Therefore, this review will discuss the mechanism of NO in overcoming MDR and recent progress of combined NO and drug delivery systems. [Display omitted]
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ISSN:0168-3659
1873-4995
1873-4995
DOI:10.1016/j.jconrel.2016.12.026