Prognosis and complete remission rate of diffuse large B‐cell lymphoma patients in standard R‐CHOP with reduction of vincristine: A retrospective study

Background and Aims The effect of stopping or reducing the dose of vincristine in diffuse large B‐cell lymphoma (DLBCL) on the outcome and prognosis of the disease is still in doubt. The present study aimed to investigate and compare the prognosis and complete remission of two R‐CHOP treatment regim...

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Published in:Health science reports Vol. 6; no. 12; pp. e1716 - n/a
Main Authors: Riasi, Fatemeh, Ataei Azimi, Sajjad, Allahyari, Abolghasem, Moeini Nodeh, Mohammad, Shakeri, Mohammad T., Kamandi, Mostafa
Format: Journal Article
Language:English
Published: United States John Wiley & Sons, Inc 01.12.2023
John Wiley and Sons Inc
Wiley
Subjects:
Age
Chemotherapy
Dehydrogenases
DLBCL
Drug dosages
Hematology
Lymphoma
Medical prognosis
Medical records
Original Research
Peripheral neuropathy
prognosis
Radiation
Remission (Medicine)
R‐CHOP
Survival analysis
Toxicity
vincristine
DLBCL
R‐CHOP
vincristine
prognosis
ISSN:2398-8835, 2398-8835
Online Access:Get full text
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Summary:Background and Aims The effect of stopping or reducing the dose of vincristine in diffuse large B‐cell lymphoma (DLBCL) on the outcome and prognosis of the disease is still in doubt. The present study aimed to investigate and compare the prognosis and complete remission of two R‐CHOP treatment regimens with and without vincristine reduction in DLBCL patients. Methods This retrospective study was conducted on newly diagnosed DLBCL patients during 2018–2021. The patients were over 18 years of age, had been histologically confirmed by a pathologist, and were under treatment with R‐CHOP regimen. The clinical information of the subjects as well as the number of treatment courses were extracted from their medical records and then compared. Results Overall, 269 patients with DLBCL were included in this study, 15.99% of whom (n = 43) had vincristine reduction. There was no significant difference between the studied factors regarding the reduction of vincristine and the complete R‐CHOP regimen (p > 0.05). Besides, no difference was observed in the 1‐year overall survival (OS) and progression‐free survival (PFS) of the patients in the two groups treated with R‐CHOP regimen with and without vincristine reduction (p > 0.05). The complete remission rates of the patients treated with R‐CHOP regimen with and without vincristine (p > 0.05) were not different either. The results of the Cox multivariate regression showed that reducing the dose of vincristine from the R‐CHOP treatment regimen had no relationship with the 1‐year OS and PFS of the DLBCL patients (hazard ratio [HR]OS = 1.59, 95% confidence interval [CI]: 3.67–0.690, HRPFS = 1.67, 95% CI: 0.798–3.82). Conclusion The results of this study showed that the reduction of vincristine from the R‐CHOP regimen in the DLBCL patients was not likely to make a difference in the 1‐year OS and PFS of the patients. However, further studies are needed on the issue.
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ISSN:2398-8835
2398-8835
DOI:10.1002/hsr2.1716