Therapeutic Enzyme-Responsive Nanoparticles for Targeted Delivery and Accumulation in Tumors

An enzyme‐responsive, paclitaxel‐loaded nanoparticle is described and assessed in vivo in a human fibrosarcoma murine xenograft. This work represents a proof‐of‐concept study demonstrating the utility of enzyme‐responsive nanoscale drug carriers capable of targeted accumulation and retention in tumo...

Full description

Saved in:

Bibliographic Details
Published in:	Advanced materials (Weinheim) Vol. 27; no. 31; pp. 4611 - 4615
Main Authors:	Callmann, Cassandra E., Barback, Christopher V., Thompson, Matthew P., Hall, David J., Mattrey, Robert F., Gianneschi, Nathan C.
Format:	Journal Article
Language:	English
Published:	Germany Blackwell Publishing Ltd 19.08.2015
Subjects:	Animals Antineoplastic Agents, Phytogenic - administration & dosage Biomedical materials Cell Line, Tumor Cohort Studies Drug Carriers - chemistry drug delivery Drug Evaluation, Preclinical enzyme-responsive Fibrosarcoma - drug therapy Fibrosarcoma - enzymology Fluorescence Resonance Energy Transfer Human Humans In vivo testing In vivo tests Matrix Metalloproteinases - metabolism Maximum Tolerated Dose Mice, Nude Micelles Microscopy, Electron, Transmission nanomaterials Nanoparticles Nanoparticles - chemistry Neoplasm Transplantation Optical Imaging Paclitaxel - administration & dosage Polymers - chemistry self-assembly stimuli-responsive Surgical implants Tumor Burden Tumors Utilities self-assembly nanomaterials drug delivery enzyme-responsive stimuli-responsive
ISSN:	0935-9648, 1521-4095
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!