Therapeutic Enzyme-Responsive Nanoparticles for Targeted Delivery and Accumulation in Tumors

An enzyme‐responsive, paclitaxel‐loaded nanoparticle is described and assessed in vivo in a human fibrosarcoma murine xenograft. This work represents a proof‐of‐concept study demonstrating the utility of enzyme‐responsive nanoscale drug carriers capable of targeted accumulation and retention in tumo...

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Bibliographic Details
Published in:Advanced materials (Weinheim) Vol. 27; no. 31; pp. 4611 - 4615
Main Authors: Callmann, Cassandra E., Barback, Christopher V., Thompson, Matthew P., Hall, David J., Mattrey, Robert F., Gianneschi, Nathan C.
Format: Journal Article
Language:English
Published: Germany Blackwell Publishing Ltd 19.08.2015
Subjects:
Animals
Antineoplastic Agents, Phytogenic - administration & dosage
Biomedical materials
Cell Line, Tumor
Cohort Studies
Drug Carriers - chemistry
drug delivery
Drug Evaluation, Preclinical
enzyme-responsive
Fibrosarcoma - drug therapy
Fibrosarcoma - enzymology
Fluorescence Resonance Energy Transfer
Human
Humans
In vivo testing
In vivo tests
Matrix Metalloproteinases - metabolism
Maximum Tolerated Dose
Mice, Nude
Micelles
Microscopy, Electron, Transmission
nanomaterials
Nanoparticles
Nanoparticles - chemistry
Neoplasm Transplantation
Optical Imaging
Paclitaxel - administration & dosage
Polymers - chemistry
self-assembly
stimuli-responsive
Surgical implants
Tumor Burden
Tumors
Utilities
self-assembly
nanomaterials
drug delivery
enzyme-responsive
stimuli-responsive
ISSN:0935-9648, 1521-4095
Online Access:Get full text
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Summary:An enzyme‐responsive, paclitaxel‐loaded nanoparticle is described and assessed in vivo in a human fibrosarcoma murine xenograft. This work represents a proof‐of‐concept study demonstrating the utility of enzyme‐responsive nanoscale drug carriers capable of targeted accumulation and retention in tumor tissue in response to overexpressed endogenous enzymes.
Bibliography:ark:/67375/WNG-8CNK3D1G-L
ArticleID:ADMA201501803
istex:9AD31BD3C45D68BF96CA26AEF67DC66BF7807584
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.201501803