Environmental Toxicant Exposure and Hypertensive Disorders of Pregnancy: Recent Findings

Purpose of Review To assess the strength of evidence for associations between environmental toxicants and hypertensive disorders of pregnancy, suggest potential biological mechanisms based on animal and in vitro studies, and highlight avenues for future research. Recent Findings Evidence is stronges...

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Bibliographic Details
Published in:Current hypertension reports Vol. 20; no. 10; pp. 87 - 10
Main Authors: Kahn, Linda G., Trasande, Leonardo
Format: Journal Article
Language:English
Published: New York Springer US 01.10.2018
Springer Nature B.V
Subjects:
Cardiology
Endocrine disruptors
Family Medicine
General Practice
Hypertension
Hypertension and Metabolic Syndrome (J Sperati
Internal Medicine
Medicine
Medicine & Public Health
Metabolic Diseases
Nephrology
Preeclampsia
Primary Care Medicine
Section Editor
Topical Collection on Hypertension and Metabolic Syndrome
Endocrine disruptors
Bisphenol A
Preeclampsia
Gestational hypertension
Pesticides
Environmental exposures
Heavy metals
ISSN:1522-6417, 1534-3111, 1534-3111
Online Access:Get full text
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Summary:Purpose of Review To assess the strength of evidence for associations between environmental toxicants and hypertensive disorders of pregnancy, suggest potential biological mechanisms based on animal and in vitro studies, and highlight avenues for future research. Recent Findings Evidence is strongest for links between persistent chemicals, including lead, cadmium, organochlorine pesticides, and polycyclic biphenyls, and preeclampsia, although associations are sometimes not detectable at low-exposure levels. Results have been inconclusive for bisphenols, phthalates, and organophosphates. Biological pathways may include oxidative stress, epigenetic changes, endocrine disruption, and abnormal placental vascularization. Additional prospective epidemiologic studies beginning in the preconception period and extending postpartum are needed to assess the life course trajectory of environmental exposures and women’s reproductive and cardiovascular health. Future studies should also consider interactions between chemicals and consider nonlinear associations. Summary These results confirm recommendations by the International Federation of Gynecology and Obstetrics, the American Society for Reproductive Medicine, the American Academy of Pediatrics, and the Endocrine Society that providers counsel their pregnant patients to limit exposure to environmental toxicants.
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ISSN:1522-6417
1534-3111
1534-3111
DOI:10.1007/s11906-018-0888-5