Cognitive dysfunction associated with COVID-19: A comprehensive neuropsychological study

Recent evidence suggests that patients suffering post-acute COVID syndrome frequently report cognitive complaints, but their characteristics and pathophysiology are unknown. This study aims to determine the characteristics of cognitive dysfunction in patients reporting cognitive complaints after COV...

Celý popis

Uložené v:
Podrobná bibliografia
Vydané v:Journal of psychiatric research Ročník 150; s. 40 - 46
Hlavní autori: Delgado-Alonso, Cristina, Valles-Salgado, Maria, Delgado-Álvarez, Alfonso, Yus, Miguel, Gómez-Ruiz, Natividad, Jorquera, Manuela, Polidura, Carmen, Gil, María José, Marcos, Alberto, Matías-Guiu, Jorge, Matías-Guiu, Jordi A.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: England Elsevier Ltd 01.06.2022
Predmet:
Cognition - physiology
Cognitive
Cognitive Dysfunction - etiology
Cognitive Dysfunction - psychology
COVID-19
COVID-19 - complications
Cross-Sectional Studies
Executive Function - physiology
Humans
Long-term COVID
Neuropsychological assessment
Neuropsychological Tests
Post-Acute COVID-19 Syndrome
COVID-19
Cognitive
Neuropsychological assessment
Long-term COVID
ISSN:0022-3956, 1879-1379, 1879-1379
On-line prístup:Získať plný text
Tagy: Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
Popis
Shrnutí:Recent evidence suggests that patients suffering post-acute COVID syndrome frequently report cognitive complaints, but their characteristics and pathophysiology are unknown. This study aims to determine the characteristics of cognitive dysfunction in patients reporting cognitive complaints after COVID-19 and to evaluate the correlation between cognitive function and anxiety, depression, sleep, and olfactory function. Cross-sectional study involving 50 patients with COVID-19 reporting cognitive complaints 9.12 ± 3.46 months after the acute infection. Patients were evaluated with a comprehensive neuropsychological protocol, and scales of fatigue, depression, anxiety, sleep and an olfactory test. Normative data and an age- and education matched healthy control group were used for comparison. COVID-19 patients showed a diminished performance on several tests evaluating attention and executive function, with alterations in processing speed, divided attention, selective attention, visual vigilance, intrinsic alertness, working memory, and inhibition; episodic memory; and visuospatial processing. Cognitive performance was correlated with olfactory dysfunction, and sleep quality and anxiety to a lesser extent, but not depression. Patients with COVID-19 reporting cognitive symptoms showed a reduced cognitive performance, especially in the attention-concentration and executive functioning, episodic memory, and visuospatial processing domains. Future studies are necessary to disentangle the specific mechanisms associated with COVID-19 cognitive dysfunction.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0022-3956
1879-1379
1879-1379
DOI:10.1016/j.jpsychires.2022.03.033