Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors

The NLRP3 inflammasome is a multimeric protein complex that initiates an inflammatory form of cell death and triggers the release of proinflammatory cytokines IL-1β and IL-18. The NLRP3 inflammasome has been implicated in a wide range of diseases, including Alzheimer’s disease, Prion diseases, type...

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Bibliographic Details
Published in:Cell death & disease Vol. 10; no. 2; p. 128
Main Authors: Yang, Yang, Wang, Huanan, Kouadir, Mohammed, Song, Houhui, Shi, Fushan
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 12.02.2019
Springer Nature B.V
Subjects:
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Alzheimer's disease
Animals
Antibodies
Apoptosis
Biochemistry
Biomedical and Life Sciences
Calcium Signaling
Cell Biology
Cell Culture
Cell death
Crystals
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diterpenes, Kaurane - pharmacology
Furans - pharmacology
Homeostasis
Humans
IL-1β
Immunology
Infectious diseases
Inflammasomes
Inflammasomes - antagonists & inhibitors
Inflammasomes - metabolism
Inflammation
Interleukin 18
Kinases
Laboratories
Life Sciences
Lysosomes - metabolism
Metals, Alkali - metabolism
Mice
Nitriles - pharmacology
NLR Family, Pyrin Domain-Containing 3 Protein - antagonists & inhibitors
NLR Family, Pyrin Domain-Containing 3 Protein - metabolism
ortho-Aminobenzoates - pharmacology
Pathogens
Protein Processing, Post-Translational
Proteins
Reactive Oxygen Species - metabolism
Regulation
Review
Review Article
Silica
Sulfonamides - pharmacology
Thiazolidines - pharmacology
Thiones - pharmacology
Uric acid
ISSN:2041-4889, 2041-4889
Online Access:Get full text
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Summary:The NLRP3 inflammasome is a multimeric protein complex that initiates an inflammatory form of cell death and triggers the release of proinflammatory cytokines IL-1β and IL-18. The NLRP3 inflammasome has been implicated in a wide range of diseases, including Alzheimer’s disease, Prion diseases, type 2 diabetes, and some infectious diseases. It has been found that a variety of stimuli including danger-associated molecular patterns (DAMPs, such as silica and uric acid crystals) and pathogen-associated molecular patterns (PAMPs) can activate NLRP3 inflammasome, but the specific regulatory mechanisms of NLRP3 inflammasome activation remain unclear. Understanding the mechanisms of NLRP3 activation will enable the development of its specific inhibitors to treat NLRP3-related diseases. In this review, we summarize current understanding of the regulatory mechanisms of NLRP3 inflammasome activation as well as inhibitors that specifically and directly target NLRP3.
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ISSN:2041-4889
2041-4889
DOI:10.1038/s41419-019-1413-8