High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities

The ability to perturb genes in human cells is crucial for elucidating gene function and holds great potential for finding therapeutic targets for diseases such as cancer. To extend the catalog of human core and context-dependent fitness genes, we have developed a high-complexity second-generation g...

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Veröffentlicht in:	Cell Jg. 163; H. 6; S. 1515
Hauptverfasser:	Hart, Traver, Chandrashekhar, Megha, Aregger, Michael, Steinhart, Zachary, Brown, Kevin R, MacLeod, Graham, Mis, Monika, Zimmermann, Michal, Fradet-Turcotte, Amelie, Sun, Song, Mero, Patricia, Dirks, Peter, Sidhu, Sachdev, Roth, Frederick P, Rissland, Olivia S, Durocher, Daniel, Angers, Stephane, Moffat, Jason
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 03.12.2015
Schlagworte:	Bayes Theorem Cell Line, Tumor CRISPR-Cas Systems Gene Knockout Techniques Gene Library Genes, Essential Humans Mutation
ISSN:	1097-4172, 1097-4172
Online-Zugang:	Weitere Angaben
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