High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities

The ability to perturb genes in human cells is crucial for elucidating gene function and holds great potential for finding therapeutic targets for diseases such as cancer. To extend the catalog of human core and context-dependent fitness genes, we have developed a high-complexity second-generation g...

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Vydané v:	Cell Ročník 163; číslo 6; s. 1515
Hlavní autori:	Hart, Traver, Chandrashekhar, Megha, Aregger, Michael, Steinhart, Zachary, Brown, Kevin R, MacLeod, Graham, Mis, Monika, Zimmermann, Michal, Fradet-Turcotte, Amelie, Sun, Song, Mero, Patricia, Dirks, Peter, Sidhu, Sachdev, Roth, Frederick P, Rissland, Olivia S, Durocher, Daniel, Angers, Stephane, Moffat, Jason
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 03.12.2015
Predmet:	Bayes Theorem Cell Line, Tumor CRISPR-Cas Systems Gene Knockout Techniques Gene Library Genes, Essential Humans Mutation
ISSN:	1097-4172, 1097-4172
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