All-trans-retinoic acid (ATRA) plus oxaliplatin plus 5-fluorouracil/leucovorin (FOLFOX) versus FOLFOX alone as palliative chemotherapy in patients with advanced hepatocellular carcinoma and extrahepatic metastasis: study protocol for a randomized controlled trial

Background Among patients with hepatocellular carcinoma (HCC), 85% of patients have an advanced disease stage at diagnosis and curative therapies cannot be performed. Prognosis has been quite poor as until recently there was no proven effective chemotherapy. Our group found that all-trans-retinoic a...

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Veröffentlicht in:	Current controlled trials in cardiovascular medicine Jg. 20; H. 1; S. 245 - 9
Hauptverfasser:	Shi, Jie, Sun, Juxian, Liu, Chang, Chai, Zongtao, Wang, Nanya, Zhang, Hui, Cheng, Shuqun
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London BioMed Central 29.04.2019 Springer Nature B.V BMC
Schlagworte:	Acids Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - adverse effects ATRA Biomedicine Cancer therapies Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - mortality Carcinoma, Hepatocellular - secondary Chemotherapy China Consent Disease Progression Double-Blind Method Extrahepatic metastasis Female Fluorouracil - administration & dosage Fluorouracil - adverse effects FOLFOX4 Health Sciences Hepatitis B Humans Illnesses Infections Kinases Leucovorin - administration & dosage Leucovorin - adverse effects Liver cancer Liver cirrhosis Liver Neoplasms - drug therapy Liver Neoplasms - mortality Liver Neoplasms - pathology Male Medicine Medicine & Public Health Metastasis Multicenter Studies as Topic Organoplatinum Compounds - administration & dosage Organoplatinum Compounds - adverse effects Palliative Care Palliative chemotherapy Progression-Free Survival Randomized Controlled Trials as Topic Statistics for Life Sciences Study Protocol Time Factors Tretinoin - administration & dosage Tretinoin - adverse effects Tumors Womens health China Asia Extrahepatic metastasis FOLFOX4 ATRA Palliative chemotherapy
ISSN:	1745-6215, 1745-6215
Online-Zugang:	Volltext
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