The lncRNA MIR2052HG regulates ERα levels and aromatase inhibitor resistance through LMTK3 by recruiting EGR1

Background Our previous genome-wide association study using the MA.27 aromatase inhibitors adjuvant trial identified SNPs in the long noncoding RNA MIR2052HG associated with breast cancer-free interval. MIR2052HG maintained ERα both by promoting AKT/FOXO3-mediated ESR1 transcription and by limiting...

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Veröffentlicht in:	Breast cancer research : BCR Jg. 21; H. 1; S. 47 - 17
Hauptverfasser:	Cairns, Junmei, Ingle, James N., Kalari, Krishna R., Shepherd, Lois E., Kubo, Michiaki, Goetz, Matthew P., Weinshilboum, Richard M., Wang, Liewei
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London BioMed Central 03.04.2019 Springer Nature B.V BMC
Schlagworte:	AKT protein Androstenedione Aromatase Aromatase Inhibitors - pharmacology Binding sites Biomarkers Biomedical and Life Sciences Biomedicine Breast cancer Cancer Research Cell Line, Tumor Cell Proliferation Cell Survival - genetics Chromatin Drug Resistance, Neoplasm - genetics Early Growth Response Protein 1 - genetics Early Growth Response Protein 1 - metabolism EGR-1 protein EGR1 Endocrine therapy ERα ESR1 protein Estrogen Receptor alpha - genetics Estrogen Receptor alpha - metabolism Estrogens Extracellular signal-regulated kinase Female Fluorescence in situ hybridization FOXO3 protein Gene expression Genome-wide association studies Genomes Humans Immunoprecipitation Kinases Ligands LMTK3 Localization Lon noncoding RNA Lymphoblastoid cell lines Medical prognosis Membrane Proteins - genetics Membrane Proteins - metabolism MIR2052HG Models, Biological Oncology Phosphorylation PKC Polymorphism, Single Nucleotide Protein kinase C Protein Stability Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Protein-tyrosine kinase Proteins Research Article Ribonucleic acid Ribosomal protein S6 kinase RNA RNA, Long Noncoding - genetics RNA-binding protein Signal Transduction Single-nucleotide polymorphism Surgical Oncology Transcription factors Transcription, Genetic Tumors Ubiquitin EGR1 Aromatase inhibitor ERα LMTK3 MIR2052HG PKC Lon noncoding RNA
ISSN:	1465-542X, 1465-5411, 1465-542X
Online-Zugang:	Volltext
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