Clinical validation of an epigenetic assay to predict negative histopathological results in repeat prostate biopsies

The DOCUMENT multicenter trial in the United States validated the performance of an epigenetic test as an independent predictor of prostate cancer risk to guide decision making for repeat biopsy. Confirming an increased negative predictive value could help avoid unnecessary repeat biopsies. We evalu...

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Veröffentlicht in:	The Journal of urology Jg. 192; H. 4; S. 1081
Hauptverfasser:	Partin, Alan W, Van Neste, Leander, Klein, Eric A, Marks, Leonard S, Gee, Jason R, Troyer, Dean A, Rieger-Christ, Kimberly, Jones, J Stephen, Magi-Galluzzi, Cristina, Mangold, Leslie A, Trock, Bruce J, Lance, Raymond S, Bigley, Joseph W, Van Criekinge, Wim, Epstein, Jonathan I
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.10.2014
Schlagworte:	Biopsy - methods DNA Methylation DNA, Neoplasm - genetics Epigenesis, Genetic Epigenomics - methods Follow-Up Studies Genes, APC Glutathione S-Transferase pi - biosynthesis Glutathione S-Transferase pi - genetics Humans Male Polymerase Chain Reaction Predictive Value of Tests Prognosis Prostate - metabolism Prostate - pathology Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Tumor Suppressor Proteins - biosynthesis Tumor Suppressor Proteins - genetics Unnecessary Procedures - utilization biopsy epigenomics prostate methylation prostatic neoplasms
ISSN:	1527-3792, 1527-3792
Online-Zugang:	Weitere Angaben
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