Antibiotic-Resistant Bugs in the 21st Century — A Clinical Super-Challenge

Drs. Cesar Arias and Barbara Murray write that we have arrived at a point as frightening as the preantibiotic era: for patients infected with multidrug-resistant bacteria, there is no magic bullet. In March 1942, a 33-year-old woman lay dying of streptococcal sepsis in a New Haven, Connecticut, hosp...

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Veröffentlicht in:The New England journal of medicine Jg. 360; H. 5; S. 439 - 443
Hauptverfasser: Arias, Cesar A, Murray, Barbara E
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States Massachusetts Medical Society 29.01.2009
Schlagworte:
Antibiotics
Drug resistance
Drug Resistance, Multiple, Bacterial - genetics
Enterococcus faecium - drug effects
Enterococcus faecium - pathogenicity
Gram-Negative Bacteria - pathogenicity
Gram-Negative Bacterial Infections - drug therapy
Hospitals
Humans
Methicillin-Resistant Staphylococcus aureus - genetics
Methicillin-Resistant Staphylococcus aureus - pathogenicity
Mutation
Staphylococcus infections
Vancomycin Resistance - genetics
United States > US
ISSN:0028-4793, 1533-4406, 1533-4406
Online-Zugang:Volltext
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Zusammenfassung:Drs. Cesar Arias and Barbara Murray write that we have arrived at a point as frightening as the preantibiotic era: for patients infected with multidrug-resistant bacteria, there is no magic bullet. In March 1942, a 33-year-old woman lay dying of streptococcal sepsis in a New Haven, Connecticut, hospital, and despite the best efforts of contemporary medical science, her doctors could not eradicate her bloodstream infection. Then they managed to obtain a small amount of a newly discovered substance called penicillin, which they cautiously injected into her. After repeated doses, her bloodstream was cleared of streptococci, she made a full recovery, and she went on to live to the age of 90. 1 Sixty-six years after her startling recovery, a report 2 described a 70-year-old man in San Francisco with endocarditis caused by vancomycin-resistant . . .
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ISSN:0028-4793
1533-4406
1533-4406
DOI:10.1056/NEJMp0804651