Guidelines on genetic evaluation and management of Lynch syndrome: a consensus statement by the US Multi-Society Task Force on colorectal cancer

The Multi-Society Task Force, in collaboration with invited experts, developed guidelines to assist health care providers with the appropriate provision of genetic testing and management of patients at risk for and affected with Lynch syndrome as follows: Figure 1 provides a colorectal cancer risk a...

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Bibliographic Details
Published in:Gastroenterology (New York, N.Y. 1943) Vol. 147; no. 2; p. 502
Main Authors: Giardiello, Francis M, Allen, John I, Axilbund, Jennifer E, Boland, C Richard, Burke, Carol A, Burt, Randall W, Church, James M, Dominitz, Jason A, Johnson, David A, Kaltenbach, Tonya, Levin, Theodore R, Lieberman, David A, Robertson, Douglas J, Syngal, Sapna, Rex, Douglas K
Format: Journal Article
Language:English
Published: United States 01.08.2014
Subjects:
Algorithms
Colorectal Neoplasms, Hereditary Nonpolyposis - diagnosis
Colorectal Neoplasms, Hereditary Nonpolyposis - genetics
Colorectal Neoplasms, Hereditary Nonpolyposis - therapy
Gastroenterology - standards
Genetic Predisposition to Disease
Genetic Testing - standards
Genetic Therapy - standards
Humans
Pedigree
Predictive Value of Tests
Prognosis
Risk Assessment
Risk Factors
Lynch Syndrome
Colorectal Cancer
Genetic Testing
ISSN:1528-0012, 1528-0012
Online Access:Get more information
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Summary:The Multi-Society Task Force, in collaboration with invited experts, developed guidelines to assist health care providers with the appropriate provision of genetic testing and management of patients at risk for and affected with Lynch syndrome as follows: Figure 1 provides a colorectal cancer risk assessment tool to screen individuals in the office or endoscopy setting; Figure 2 illustrates a strategy for universal screening for Lynch syndrome by tumor testing of patients diagnosed with colorectal cancer; Figures 3-6 provide algorithms for genetic evaluation of affected and at-risk family members of pedigrees with Lynch syndrome; Table 10 provides guidelines for screening at-risk and affected persons with Lynch syndrome; and Table 12 lists the guidelines for the management of patients with Lynch syndrome. A detailed explanation of Lynch syndrome and the methodology utilized to derive these guidelines, as well as an explanation of, and supporting literature for, these guidelines are provided.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Instructional Material/Guideline-3
ObjectType-Review-4
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ISSN:1528-0012
1528-0012
DOI:10.1053/j.gastro.2014.04.001