Large community-acquired Legionnaires’ disease outbreak caused by Legionella pneumophila serogroup 1, Italy, July to August 2018

In July 2018, a large outbreak of Legionnaires’ disease (LD) caused by Legionella pneumophila serogroup 1 (Lp1) occurred in Bresso, Italy. Fifty-two cases were diagnosed, including five deaths. We performed an epidemiological investigation and prepared a map of the places cases visited during the in...

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Vydáno v:Euro surveillance : bulletin européen sur les maladies transmissibles Ročník 25; číslo 20; s. 1
Hlavní autoři: Faccini, Marino, Russo, Antonio Giampiero, Bonini, Maira, Tunesi, Sara, Murtas, Rossella, Sandrini, Monica, Senatore, Sabrina, Lamberti, Anna, Ciconali, Giorgio, Cammarata, Serafina, Barrese, Eros, Ceriotti, Valentina, Vitaliti, Sonia, Foti, Marina, Gentili, Gabriella, Graziano, Elisabetta, Panciroli, Emerico, Bosio, Marco, Gramegna, Maria, Cereda, Danilo, Perno, Carlo Federico, Mazzola, Ester, Campisi, Daniela, Aulicino, Gianuario, Castaldi, Silvana, Girolamo, Antonietta, Caporali, Maria Grazia, Scaturro, Maria, Rota, Maria Cristina, Ricci, Maria Luisa
Médium: Journal Article
Jazyk:angličtina
Vydáno: Sweden Centre Europeen pour la Surveillance Epidemiologique du SIDA (European Centre for the Epidemiological Monitoring of AIDS) 21.05.2020
European Centre for Disease Prevention and Control (ECDC)
Témata:
Aged
Case-Control Studies
Cross-Over Studies
Disease Outbreaks
Epidemics
Epidemiology
Humans
Italy - epidemiology
Legionella pneumophila - classification
Legionella pneumophila - genetics
Legionella pneumophila - isolation & purification
Legionnaires' disease
Legionnaires' Disease - diagnosis
Legionnaires' Disease - epidemiology
Legionnaires' Disease - microbiology
Male
Medical research
Middle Aged
Molecular Typing
Outbreaks
Risk factors
Sequence Analysis, DNA
Serogroup
Serotyping
Italy
legionnaires’ disease
Italy
Legionella pneumophila
outbreak
ISSN:1560-7917, 1025-496X, 1560-7917
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Shrnutí:In July 2018, a large outbreak of Legionnaires’ disease (LD) caused by Legionella pneumophila serogroup 1 (Lp1) occurred in Bresso, Italy. Fifty-two cases were diagnosed, including five deaths. We performed an epidemiological investigation and prepared a map of the places cases visited during the incubation period. All sites identified as potential sources were investigated and sampled. Association between heavy rainfall and LD cases was evaluated in a case-crossover study. We also performed a case–control study and an aerosol dispersion investigation model. Lp1 was isolated from 22 of 598 analysed water samples; four clinical isolates were typed using monoclonal antibodies and sequence-based typing. Four Lp1 human strains were ST23, of which two were Philadelphia and two were France-Allentown subgroup. Lp1 ST23 France-Allentown was isolated only from a public fountain. In the case-crossover study, extreme precipitation 5–6 days before symptom onset was associated with increased LD risk. The aerosol dispersion model showed that the fountain matched the case distribution best. The case–control study demonstrated a significant eightfold increase in risk for cases residing near the public fountain. The three studies and the matching of clinical and environmental Lp1 strains identified the fountain as the source responsible for the epidemic.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Correspondence: Marino Faccini (mfaccini@ats-milano.it)
ISSN:1560-7917
1025-496X
1560-7917
DOI:10.2807/1560-7917.ES.2020.25.20.1900523