Palladium-Catalyzed Heck Cross-Coupling Reactions in Water: A Comprehensive Review

Palladium-catalyzed cross-coupling reactions have emerged as one of the most versatile tools in organic chemistry. Extensive efforts were made to adapt these reactions to aqueous media, not only for the purpose of environmental conservation but also to expand the scope, increase the efficiency and i...

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Bibliographic Details
Published in:Catalysis letters Vol. 148; no. 2; pp. 489 - 511
Main Authors: Christoffel, Fadri, Ward, Thomas R.
Format: Journal Article
Language:English
Published: New York Springer US 01.02.2018
Springer
Springer Nature B.V
Subjects:
Aqueous environments
Aqueous solutions
Biocompatibility
Catalysis
Catalysts
Chemical reactions
Chemistry
Chemistry and Materials Science
Cross coupling
Industrial Chemistry/Chemical Engineering
Nanoparticles
Organic chemistry
Organometallic Chemistry
Palladium
Palladium catalysts
Perspective
Physical Chemistry
Substitution reactions
Heck–Mizoroki reaction
Aqueous catalysis
Palladium
Green chemistry
Cross-coupling
ISSN:1011-372X, 1572-879X
Online Access:Get full text
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Summary:Palladium-catalyzed cross-coupling reactions have emerged as one of the most versatile tools in organic chemistry. Extensive efforts were made to adapt these reactions to aqueous media, not only for the purpose of environmental conservation but also to expand the scope, increase the efficiency and implement bio-compatible protocols. Among different palladium cross-coupling reactions, the Heck reaction turned out to be the most challenging in an aqueous environment. This led to various original developments in catalyst design. This review summarizes the different approaches pursued to perform Heck reactions in neat water as well as aqueous mixtures. Both, homogeneous and immobilized catalysts, including nanoparticles are presented herein. Graphical Abstract
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ISSN:1011-372X
1572-879X
DOI:10.1007/s10562-017-2285-0