Mechanistic insights into the effect of humidity on airborne influenza virus survival, transmission and incidence

Influenza incidence and seasonality, along with virus survival and transmission, appear to depend at least partly on humidity, and recent studies have suggested that absolute humidity (AH) is more important than relative humidity (RH) in modulating observed patterns. In this perspective article, we...

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Vydané v:Journal of the Royal Society interface Ročník 16; číslo 150; s. 20180298
Hlavní autori: Marr, Linsey C, Tang, Julian W, Van Mullekom, Jennifer, Lakdawala, Seema S
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: England 01.01.2019
Predmet:
Humans
Humidity
Incidence
Influenza A virus
Influenza, Human - epidemiology
Influenza, Human - transmission
Microbial Viability
Models, Biological
temperature
humidity
environment
transmission
flu
aerosol
ISSN:1742-5662, 1742-5662
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Popis
Shrnutí:Influenza incidence and seasonality, along with virus survival and transmission, appear to depend at least partly on humidity, and recent studies have suggested that absolute humidity (AH) is more important than relative humidity (RH) in modulating observed patterns. In this perspective article, we re-evaluate studies of influenza virus survival in aerosols, transmission in animal models and influenza incidence to show that the combination of temperature and RH is equally valid as AH as a predictor. Collinearity must be considered, as higher levels of AH are only possible at higher temperatures, where it is well established that virus decay is more rapid. In studies of incidence that employ meteorological data, outdoor AH may be serving as a proxy for indoor RH in temperate regions during the wintertime heating season. Finally, we present a mechanistic explanation based on droplet evaporation and its impact on droplet physics and chemistry for why RH is more likely than AH to modulate virus survival and transmission.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1742-5662
1742-5662
DOI:10.1098/rsif.2018.0298