Therapeutic potential of Clostridium butyricum anticancer effects in colorectal cancer

Probiotic roles of Clostridium butyricum (C.B) are involved in regulating disease and cancers, yet the mechanistic basis for these regulatory roles remains largely unknown. Here, we demonstrate that C.B reprograms the proliferation, migration, stemness, and tumor growth in CRC by regulating pivotal...

Full description

Saved in:

Bibliographic Details
Published in:	Gut microbes Vol. 15; no. 1; p. 2186114
Main Authors:	Xu, Hui, Luo, Haidan, Zhang, Jiayu, Li, Kai, Lee, Mong-Hong
Format:	Journal Article
Language:	English
Published:	United States Taylor & Francis 31.12.2023 Taylor & Francis Group
Subjects:	5-FU Anti-PD1 Cell Line, Tumor Cell Proliferation Clostridium butyricum Colorectal Neoplasms - pathology Fluorouracil - pharmacology Fluorouracil - therapeutic use Gastrointestinal Microbiome Humans immunotherapy MYC Research Paper TYMS ubiquitination Clostridium butyricum ubiquitination MYC immunotherapy Anti-PD1 TYMS 5-FU
ISSN:	1949-0976, 1949-0984, 1949-0984
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Abstract	Probiotic roles of Clostridium butyricum (C.B) are involved in regulating disease and cancers, yet the mechanistic basis for these regulatory roles remains largely unknown. Here, we demonstrate that C.B reprograms the proliferation, migration, stemness, and tumor growth in CRC by regulating pivotal signal molecules including MYC. Destabilization of MYC by C.B supplementation suppresses cancer cell proliferation/metastasis, sensitizes 5-FU treatment, and boosts responsiveness of anti-PD1 therapy. MYC is a transcriptional regulator of Thymidylate synthase (TYMS), a key target of the 5-FU. Also MYC is known to impact on PD-1 expression. Mechanistically, C.B treatment of CRC cells results in MYC degradation by enhancing proteasome-mediated ubiquitination, thereby mitigating MYC-mediated 5-FU resistance and boosting anti-PD1 immunotherapeutic efficacy. Together, our findings uncover previously unappreciated links between C.B and CRC cell signaling, providing insight into the tumorigenesis modulating mechanisms of C.B in boosting chemo/immune therapies.
AbstractList	Probiotic roles of (C.B) are involved in regulating disease and cancers, yet the mechanistic basis for these regulatory roles remains largely unknown. Here, we demonstrate that C.B reprograms the proliferation, migration, stemness, and tumor growth in CRC by regulating pivotal signal molecules including MYC. Destabilization of MYC by C.B supplementation suppresses cancer cell proliferation/metastasis, sensitizes 5-FU treatment, and boosts responsiveness of anti-PD1 therapy. MYC is a transcriptional regulator of Thymidylate synthase (TYMS), a key target of the 5-FU. Also MYC is known to impact on PD-1 expression. Mechanistically, C.B treatment of CRC cells results in MYC degradation by enhancing proteasome-mediated ubiquitination, thereby mitigating MYC-mediated 5-FU resistance and boosting anti-PD1 immunotherapeutic efficacy. Together, our findings uncover previously unappreciated links between C.B and CRC cell signaling, providing insight into the tumorigenesis modulating mechanisms of C.B in boosting chemo/immune therapies. Probiotic roles of Clostridium butyricum (C.B) are involved in regulating disease and cancers, yet the mechanistic basis for these regulatory roles remains largely unknown. Here, we demonstrate that C.B reprograms the proliferation, migration, stemness, and tumor growth in CRC by regulating pivotal signal molecules including MYC. Destabilization of MYC by C.B supplementation suppresses cancer cell proliferation/metastasis, sensitizes 5-FU treatment, and boosts responsiveness of anti-PD1 therapy. MYC is a transcriptional regulator of Thymidylate synthase (TYMS), a key target of the 5-FU. Also MYC is known to impact on PD-1 expression. Mechanistically, C.B treatment of CRC cells results in MYC degradation by enhancing proteasome-mediated ubiquitination, thereby mitigating MYC-mediated 5-FU resistance and boosting anti-PD1 immunotherapeutic efficacy. Together, our findings uncover previously unappreciated links between C.B and CRC cell signaling, providing insight into the tumorigenesis modulating mechanisms of C.B in boosting chemo/immune therapies. ABSTRACTProbiotic roles of Clostridium butyricum (C.B) are involved in regulating disease and cancers, yet the mechanistic basis for these regulatory roles remains largely unknown. Here, we demonstrate that C.B reprograms the proliferation, migration, stemness, and tumor growth in CRC by regulating pivotal signal molecules including MYC. Destabilization of MYC by C.B supplementation suppresses cancer cell proliferation/metastasis, sensitizes 5-FU treatment, and boosts responsiveness of anti-PD1 therapy. MYC is a transcriptional regulator of Thymidylate synthase (TYMS), a key target of the 5-FU. Also MYC is known to impact on PD-1 expression. Mechanistically, C.B treatment of CRC cells results in MYC degradation by enhancing proteasome-mediated ubiquitination, thereby mitigating MYC-mediated 5-FU resistance and boosting anti-PD1 immunotherapeutic efficacy. Together, our findings uncover previously unappreciated links between C.B and CRC cell signaling, providing insight into the tumorigenesis modulating mechanisms of C.B in boosting chemo/immune therapies. Probiotic roles of Clostridium butyricum (C.B) are involved in regulating disease and cancers, yet the mechanistic basis for these regulatory roles remains largely unknown. Here, we demonstrate that C.B reprograms the proliferation, migration, stemness, and tumor growth in CRC by regulating pivotal signal molecules including MYC. Destabilization of MYC by C.B supplementation suppresses cancer cell proliferation/metastasis, sensitizes 5-FU treatment, and boosts responsiveness of anti-PD1 therapy. MYC is a transcriptional regulator of Thymidylate synthase (TYMS), a key target of the 5-FU. Also MYC is known to impact on PD-1 expression. Mechanistically, C.B treatment of CRC cells results in MYC degradation by enhancing proteasome-mediated ubiquitination, thereby mitigating MYC-mediated 5-FU resistance and boosting anti-PD1 immunotherapeutic efficacy. Together, our findings uncover previously unappreciated links between C.B and CRC cell signaling, providing insight into the tumorigenesis modulating mechanisms of C.B in boosting chemo/immune therapies.Probiotic roles of Clostridium butyricum (C.B) are involved in regulating disease and cancers, yet the mechanistic basis for these regulatory roles remains largely unknown. Here, we demonstrate that C.B reprograms the proliferation, migration, stemness, and tumor growth in CRC by regulating pivotal signal molecules including MYC. Destabilization of MYC by C.B supplementation suppresses cancer cell proliferation/metastasis, sensitizes 5-FU treatment, and boosts responsiveness of anti-PD1 therapy. MYC is a transcriptional regulator of Thymidylate synthase (TYMS), a key target of the 5-FU. Also MYC is known to impact on PD-1 expression. Mechanistically, C.B treatment of CRC cells results in MYC degradation by enhancing proteasome-mediated ubiquitination, thereby mitigating MYC-mediated 5-FU resistance and boosting anti-PD1 immunotherapeutic efficacy. Together, our findings uncover previously unappreciated links between C.B and CRC cell signaling, providing insight into the tumorigenesis modulating mechanisms of C.B in boosting chemo/immune therapies.
Author	Li, Kai Luo, Haidan Lee, Mong-Hong Xu, Hui Zhang, Jiayu
Author_xml	– sequence: 1 givenname: Hui surname: Xu fullname: Xu, Hui organization: The Sixth Affiliated Hospital, Sun Yat-sen University – sequence: 2 givenname: Haidan surname: Luo fullname: Luo, Haidan organization: The Sixth Affiliated Hospital, Sun Yat-sen University – sequence: 3 givenname: Jiayu surname: Zhang fullname: Zhang, Jiayu organization: The Sixth Affiliated Hospital, Sun Yat-sen University – sequence: 4 givenname: Kai surname: Li fullname: Li, Kai organization: The Sixth Affiliated Hospital, Sun Yat-sen University – sequence: 5 givenname: Mong-Hong orcidid: 0000-0001-8675-8215 surname: Lee fullname: Lee, Mong-Hong email: limh33@mail.sysu.edu.cn organization: The Sixth Affiliated Hospital, Sun Yat-sen University
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/36941257$$D View this record in MEDLINE/PubMed
BookMark	eNqFUk1v1DAQjVARLaU_AZQjl13GH3FscQC04qNSJS6Fq-U449ZVEi-2U7T_Hi_ZrigH8MXjmffejDzveXUyhQmr6iWBNQEJb4jiClQr1hQoW1MiBSH8SXW2z69ASX5yjFtxWl2kdAflcN6CYM-qUyYUJ7Rpz6rv17cYzRbn7G29DRmn7M1QB1dvhpBy9L2fx7qb8y56WyJT6tZMFmONzqHNqfZTbcMQYnkU5lJ8UT11Zkh4cbjPq2-fPl5vvqyuvn6-3Hy4WtmGNXlFKOGAivWAAB12hkrmROu4JUr1nEFnkAsh-r61zshOOCfRSNGrHrjkhp1Xl4tuH8yd3kY_mrjTwXj9OxHijTaxTDyg5lxiw6Wi1nWc0aYDYYRVRCI4SqgqWu8Wre3cjdjb8hXRDI9EH1cmf6tvwr0mAEwCb4vC64NCDD9mTFmPPlkcBjNhmJOmbWnPOGugQF_92ezY5WEzBdAsABtDShHdEUJA702gH0yg9ybQBxMU3tu_eNZnk33Yz-yH_7LfL2w_uRBH8zPEodfZ7Mp-XSyr9Umzf0v8Arxyy3A
CitedBy_id	crossref_primary_10_1016_j_ijbiomac_2023_125794 crossref_primary_10_1016_j_jare_2025_05_036 crossref_primary_10_1021_acs_jafc_5c09135 crossref_primary_10_1080_19490976_2025_2552344 crossref_primary_10_1007_s00018_025_05782_x crossref_primary_10_1002_mog2_70015 crossref_primary_10_1186_s12964_024_01615_9 crossref_primary_10_1186_s12917_024_04372_6 crossref_primary_10_1016_j_apsb_2024_09_015 crossref_primary_10_1016_j_semcancer_2025_06_012 crossref_primary_10_1002_ijc_35342 crossref_primary_10_1039_D5FO00940E crossref_primary_10_1038_s41467_024_46521_3 crossref_primary_10_3389_fimmu_2025_1600863 crossref_primary_10_1002_imt2_160 crossref_primary_10_1016_j_apsb_2025_05_040 crossref_primary_10_1002_mco2_70265 crossref_primary_10_1016_j_cotox_2023_100423 crossref_primary_10_3389_fonc_2025_1524887 crossref_primary_10_1097_CM9_0000000000002955 crossref_primary_10_1002_advs_202500304 crossref_primary_10_1038_s41579_023_00973_4 crossref_primary_10_1080_87559129_2024_2414908 crossref_primary_10_1186_s12967_024_05135_5 crossref_primary_10_1016_j_cellimm_2025_105026 crossref_primary_10_1016_j_drup_2025_101311 crossref_primary_10_1177_17588359231204854 crossref_primary_10_1186_s12943_024_02046_3 crossref_primary_10_1016_j_foodres_2024_114682 crossref_primary_10_1007_s12602_025_10547_w crossref_primary_10_1016_j_gene_2024_149208 crossref_primary_10_1016_j_phrs_2024_107148 crossref_primary_10_3389_fmicb_2025_1635409 crossref_primary_10_3390_ijms252212151 crossref_primary_10_1016_j_phymed_2025_156766 crossref_primary_10_1016_j_nantod_2025_102742 crossref_primary_10_3390_cancers15092570 crossref_primary_10_1615_CritRevOncog_2025058633 crossref_primary_10_1038_s41467_025_57603_1 crossref_primary_10_1007_s12032_024_02480_9 crossref_primary_10_1016_j_jep_2024_118955 crossref_primary_10_1016_j_biopha_2023_115484 crossref_primary_10_1038_s44321_024_00177_0 crossref_primary_10_1016_j_ejso_2025_110482 crossref_primary_10_1016_j_biopha_2025_118559 crossref_primary_10_1016_j_critrevonc_2025_104832 crossref_primary_10_3389_fgene_2025_1618472 crossref_primary_10_1002_cam4_70987 crossref_primary_10_1038_s41467_025_60180_y crossref_primary_10_1128_msystems_01567_24
Cites_doi	10.1038/s41571-018-0006-2 10.1038/s41586-022-04985-7 10.1038/s41416-020-0779-9 10.3322/caac.21654 10.1007/PL00000826 10.1016/j.chom.2014.02.007 10.1038/s41591-018-0014-x 10.1016/S0925-4439(02)00082-0 10.1038/s41571-022-00634-0 10.1016/j.ccell.2015.07.004 10.1093/gastro/got022 10.1038/s41575-019-0209-8 10.1002/cac2.12200 10.1016/j.semcancer.2022.07.009 10.1016/j.semcancer.2006.03.009 10.1038/nrgastro.2017.20 10.1038/s41467-022-28340-6 10.4049/jimmunol.2000353 10.1016/j.cell.2018.07.038 10.1016/j.ejca.2010.07.011 10.1038/nature12721 10.1093/gastro/gov046 10.1038/s41422-019-0257-1 10.1007/s13238-018-0543-6 10.1016/j.cell.2022.02.027 10.1073/pnas.1110287109 10.1038/s41571-021-00549-2 10.1136/jitc-2021-002772 10.1093/gastro/gox031 10.1080/19490976.2021.1907272 10.1038/ncomms8530 10.1038/s41591-022-01694-6 10.1038/s41580-020-0215-2
ContentType	Journal Article
Copyright	2023 The Author(s). Published with license by Taylor & Francis Group, LLC. 2023 2023 The Author(s). Published with license by Taylor & Francis Group, LLC. 2023 The Author(s)
Copyright_xml	– notice: 2023 The Author(s). Published with license by Taylor & Francis Group, LLC. 2023 – notice: 2023 The Author(s). Published with license by Taylor & Francis Group, LLC. 2023 The Author(s)
DBID	0YH AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 5PM DOA
DOI	10.1080/19490976.2023.2186114
DatabaseName	Taylor & Francis Open Access CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic
DatabaseTitleList	MEDLINE MEDLINE - Academic
Database_xml	– sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: 0YH name: Taylor & Francis Open Access url: https://www.tandfonline.com sourceTypes: Publisher – sequence: 4 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Biology
DocumentTitleAlternate	H. XU ET AL
EISSN	1949-0984
ExternalDocumentID	oai_doaj_org_article_448e54892cfb4325b06a6c918e0f2129 PMC10038047 36941257 10_1080_19490976_2023_2186114 2186114
Genre	Research Article Research Support, Non-U.S. Gov't Journal Article
GrantInformation_xml	– fundername: National Natural Science Foundation of China grantid: 81630072 – fundername: Shenzhen Municipal Government of China grantid: KQTD20170810160226082
GroupedDBID	--- 00X 0YH 30N 4.4 53G ABPEM ACGFS ACTIO ADBBV ADCVX AEISY AGYJP AIJEM AIYEW ALMA_UNASSIGNED_HOLDINGS AOIJS AQRUH AQTUD BABNJ BAWUL BLEHA CCCUG DGEBU DIK DKSSO EBS EMOBN F5P GROUPED_DOAJ H13 HYE KYCEM LJTGL M4Z MM. O9- OK1 RPM SNACF SV3 TDBHL TFL TFW TR2 TTHFI AAYXX CITATION ABCCY C1A CGR CUY CVF ECM EIF EJD IPNFZ NPM OVD RIG TEORI TFT 7X8 5PM
ID	FETCH-LOGICAL-c535t-12140e93d0e00beba283f67f4c199d430bae4666dd7cfa8b6ff8ea86d9d0484a3
IEDL.DBID	DOA
ISICitedReferencesCount	61
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000951072000001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	1949-0976 1949-0984
IngestDate	Fri Oct 03 12:39:02 EDT 2025 Tue Nov 04 02:07:52 EST 2025 Sun Nov 09 13:28:45 EST 2025 Thu Jan 02 22:52:02 EST 2025 Sat Nov 29 05:35:15 EST 2025 Tue Nov 18 22:16:30 EST 2025 Mon Oct 20 23:46:47 EDT 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	1
Keywords	Clostridium butyricum ubiquitination MYC immunotherapy Anti-PD1 TYMS 5-FU
Language	English
License	open-access: http://creativecommons.org/licenses/by/4.0/: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c535t-12140e93d0e00beba283f67f4c199d430bae4666dd7cfa8b6ff8ea86d9d0484a3
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ORCID	0000-0001-8675-8215
OpenAccessLink	https://doaj.org/article/448e54892cfb4325b06a6c918e0f2129
PMID	36941257
PQID	2789234350
PQPubID	23479
ParticipantIDs	crossref_primary_10_1080_19490976_2023_2186114 crossref_citationtrail_10_1080_19490976_2023_2186114 pubmed_primary_36941257 proquest_miscellaneous_2789234350 doaj_primary_oai_doaj_org_article_448e54892cfb4325b06a6c918e0f2129 pubmedcentral_primary_oai_pubmedcentral_nih_gov_10038047 informaworld_taylorfrancis_310_1080_19490976_2023_2186114
PublicationCentury	2000
PublicationDate	2023-12-31
PublicationDateYYYYMMDD	2023-12-31
PublicationDate_xml	– month: 12 year: 2023 text: 2023-12-31 day: 31
PublicationDecade	2020
PublicationPlace	United States
PublicationPlace_xml	– name: United States
PublicationTitle	Gut microbes
PublicationTitleAlternate	Gut Microbes
PublicationYear	2023
Publisher	Taylor & Francis Taylor & Francis Group
Publisher_xml	– name: Taylor & Francis – name: Taylor & Francis Group
References	Choi HH (e_1_3_7_35_1) 2020 e_1_3_7_21_1 e_1_3_7_20_1 e_1_3_7_23_1 e_1_3_7_22_1 e_1_3_7_25_1 e_1_3_7_24_1 e_1_3_7_27_1 e_1_3_7_26_1 e_1_3_7_29_1 e_1_3_7_28_1 e_1_3_7_30_1 e_1_3_7_32_1 e_1_3_7_10_1 e_1_3_7_31_1 e_1_3_7_11_1 e_1_3_7_34_1 e_1_3_7_12_1 e_1_3_7_33_1 e_1_3_7_13_1 e_1_3_7_14_1 e_1_3_7_15_1 e_1_3_7_16_1 e_1_3_7_17_1 e_1_3_7_18_1 e_1_3_7_19_1 e_1_3_7_3_1 e_1_3_7_2_1 e_1_3_7_5_1 e_1_3_7_4_1 e_1_3_7_7_1 e_1_3_7_6_1 e_1_3_7_9_1 e_1_3_7_8_1
References_xml	– ident: e_1_3_7_23_1 doi: 10.1038/s41571-018-0006-2 – ident: e_1_3_7_26_1 doi: 10.1038/s41586-022-04985-7 – ident: e_1_3_7_30_1 doi: 10.1038/s41416-020-0779-9 – ident: e_1_3_7_3_1 doi: 10.3322/caac.21654 – ident: e_1_3_7_13_1 doi: 10.1007/PL00000826 – ident: e_1_3_7_6_1 doi: 10.1016/j.chom.2014.02.007 – ident: e_1_3_7_28_1 doi: 10.1038/s41591-018-0014-x – ident: e_1_3_7_14_1 doi: 10.1016/S0925-4439(02)00082-0 – ident: e_1_3_7_22_1 doi: 10.1038/s41571-022-00634-0 – ident: e_1_3_7_33_1 doi: 10.1016/j.ccell.2015.07.004 – ident: e_1_3_7_4_1 doi: 10.1093/gastro/got022 – ident: e_1_3_7_9_1 doi: 10.1038/s41575-019-0209-8 – ident: e_1_3_7_7_1 doi: 10.1002/cac2.12200 – ident: e_1_3_7_17_1 doi: 10.1016/j.semcancer.2022.07.009 – ident: e_1_3_7_12_1 doi: 10.1016/j.semcancer.2006.03.009 – ident: e_1_3_7_21_1 doi: 10.1038/nrgastro.2017.20 – ident: e_1_3_7_18_1 doi: 10.1038/s41467-022-28340-6 – ident: e_1_3_7_25_1 doi: 10.4049/jimmunol.2000353 – ident: e_1_3_7_8_1 doi: 10.1016/j.cell.2018.07.038 – ident: e_1_3_7_20_1 doi: 10.1016/j.ejca.2010.07.011 – ident: e_1_3_7_27_1 doi: 10.1038/nature12721 – start-page: 2000681 volume-title: EGF relaYs signals to COP1 and facilitates FOXO4 degradation to promote Tumorigenesis. Advanced science year: 2020 ident: e_1_3_7_35_1 – ident: e_1_3_7_2_1 doi: 10.1093/gastro/gov046 – ident: e_1_3_7_32_1 doi: 10.1038/s41422-019-0257-1 – ident: e_1_3_7_10_1 doi: 10.1007/s13238-018-0543-6 – ident: e_1_3_7_19_1 doi: 10.1016/j.cell.2022.02.027 – ident: e_1_3_7_31_1 doi: 10.1073/pnas.1110287109 – ident: e_1_3_7_15_1 doi: 10.1038/s41571-021-00549-2 – ident: e_1_3_7_29_1 doi: 10.1136/jitc-2021-002772 – ident: e_1_3_7_5_1 doi: 10.1093/gastro/gox031 – ident: e_1_3_7_11_1 doi: 10.1080/19490976.2021.1907272 – ident: e_1_3_7_34_1 doi: 10.1038/ncomms8530 – ident: e_1_3_7_24_1 doi: 10.1038/s41591-022-01694-6 – ident: e_1_3_7_16_1 doi: 10.1038/s41580-020-0215-2
SSID	ssj0000447063
Score	2.5581598
Snippet	Probiotic roles of Clostridium butyricum (C.B) are involved in regulating disease and cancers, yet the mechanistic basis for these regulatory roles remains... Probiotic roles of (C.B) are involved in regulating disease and cancers, yet the mechanistic basis for these regulatory roles remains largely unknown. Here, we... ABSTRACTProbiotic roles of Clostridium butyricum (C.B) are involved in regulating disease and cancers, yet the mechanistic basis for these regulatory roles...
SourceID	doaj pubmedcentral proquest pubmed crossref informaworld
SourceType	Open Website Open Access Repository Aggregation Database Index Database Enrichment Source Publisher
StartPage	2186114
SubjectTerms	5-FU Anti-PD1 Cell Line, Tumor Cell Proliferation Clostridium butyricum Colorectal Neoplasms - pathology Fluorouracil - pharmacology Fluorouracil - therapeutic use Gastrointestinal Microbiome Humans immunotherapy MYC Research Paper TYMS ubiquitination
SummonAdditionalLinks	– databaseName: Taylor & Francis Open Access dbid: 0YH link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1LT9wwELYqSqVeePQBCy1yJa7ZOrE3jo8FFXFAqAeK4GTZsd2uBAnazVbi33cmdrYsKuLQHvOYyI_xeMaZ-T5CDgXiSwprMoTrzoQLIqu8kZnLnSlrZYzsC2kvz-T5eXV1pb6lbMJ5SqvEGDpEoIjeVuPiNnY-ZMR9hrhbMdhGx0j9PUZSpRyprF8WEJpg_MWuT5fHLEwIGfnUUCpDsaGO56kvrexQPZD_IxjTvzmjj3MqH2xSJ5v_oXtbZCN5qPRLVKlt8sI3b8iryFl5_5ZcXvyp2KJ3bYfZRvB6G-jxTYskIG66uKV20d3j0eIthZlDS1v7GU25I3TaUMTKRlsLkvHhO_L95OvF8WmWyBmyesInXZYXEJp5xR3zjFlvDfgpoZRB1LlSTnBmjRcQGzkn62AqW4YASlCVTjkwGsLw92StaRu_S6jw4CiIiS1LXwgjc8ulL7HAF8HLVMFGRAwTouuEXI4EGjc6TwCnw5BpHDKdhmxExkuxuwjd8ZzAEc728mVE3u5vtLMfOi1kDeGshyhPFXWwghcTy0pU6rzyLIAboEZEPdQV3fUHLyGypGj-TAM-DYqlYZXjrxvT-HYx11ivXHBwbWEwdqKiLZvJsRYZLO-IVCsquNKP1SfN9GePJJ7jj2Em5N4_NHqfvMbLCH75gax1s4X_SNbrX910PjvoV-NvK6Yu9A priority: 102 providerName: Taylor & Francis
Title	Therapeutic potential of Clostridium butyricum anticancer effects in colorectal cancer
URI	https://www.tandfonline.com/doi/abs/10.1080/19490976.2023.2186114 https://www.ncbi.nlm.nih.gov/pubmed/36941257 https://www.proquest.com/docview/2789234350 https://pubmed.ncbi.nlm.nih.gov/PMC10038047 https://doaj.org/article/448e54892cfb4325b06a6c918e0f2129
Volume	15
WOSCitedRecordID	wos000951072000001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1949-0984 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000447063 issn: 1949-0976 databaseCode: DOA dateStart: 20200101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVAWR databaseName: Taylor & Francis Journals Complete customDbUrl: eissn: 1949-0984 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000447063 issn: 1949-0976 databaseCode: TFW dateStart: 20100101 isFulltext: true titleUrlDefault: https://www.tandfonline.com providerName: Taylor & Francis – providerCode: PRVAWR databaseName: Taylor & Francis Open Access customDbUrl: eissn: 1949-0984 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000447063 issn: 1949-0976 databaseCode: 0YH dateStart: 20201101 isFulltext: true titleUrlDefault: https://www.tandfonline.com providerName: Taylor & Francis
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV07b9swECbaoAW6FH3XfQQs0FUOKdKkODZBjQxF0MFN3YkgRRI1kEiBIwfIv8-dKDt2UMBLFw2UKIi84_GOuvs-Qr5KxJeU3hUI113IkGRRRaeLwINTtXFO94W05z_02Vk1n5ufW1RfmBOW4YHzxB1B-BDBqzZlnbwU5cQzhS_hVWQJzG5fuse02Qqmehsspc40ahCkY06QVuvynYodYRs2jZE7fIysTJzLnY2px-9_gF76Lx_0YSrl1t40fUGeD04l_ZYH85I8is0r8jTTTN6-Juez-yIretV2mCAEj7eJnly0yNsRFqtL6lfdLZ4GXlKYbDSOdVzSId2DLhqK8NZoHqFnvvmG_Jp-n52cFgOfQlFPxKQreAnRVDQisMiYj96Ba5GUTrLmxgQpmHdRQjgTgq6Tq7xKCeRWqWACrHPpxFty0LRNfE-ojLC3y4lXKpbSae6FjgprchFvzJRsROR6Mm09gI0j58WF5QMm6VoGFmVgBxmMyHjT7SqjbezrcIyS2jyMYNl9A6iQHVTI7lOhETHbcrZdf1aSMrGJFXs-4MtaKSwsTPzb4prYrq4tlhiXArxRmIx3WUk2nymwfBiM5YhUO-qzM47dO83ibw_-zfFfLpP6w_8Y-UfyDAeTgSs_kYNuuYqfyZP6pltcLw_JY_bnFK56Xh32ywuus-nvO86sIJI
linkProvider	Directory of Open Access Journals
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELZQC4JLecOWl5G4ZnFiJ46PpWJVxLKnpfRm2bENK7VJtc1W6r_vTJwsuxWoB7jGmcixx-MZe-b7CPkgEF9SWJMgXHciXBBJ6Y1MXOpMUSljZFdIezyVs1l5cqI2a2EwrRJj6BCBIjpbjYsbD6OHlLiPEHgrBvvoGLm_x8iqlCKX9W4Oey3i588nP9bnLEwIGQnVUCpBsaGQ529f2tqiOiT_Gzimf_JGbyZVbuxSk4f_4_8ekb3eR6UHUakekzu-fkLuRdbKq6fkeP67ZoueNy3mG8HrTaCHpw3SgLjF6ozaVXuFh4tnFOYObW3ll7TPHqGLmiJaNlpbkIyNz8j3yef54VHS0zMkVc7zNkkzCM684o55xqy3BjyVUMggqlQpJzizxguIjpyTVTClLUIANSgLpxyYDWH4c7JTN7V_Sajw4CqI3BaFz4SRqeXSF1jii_BlKmMjIoYZ0VWPXY4UGqc67SFOhyHTOGS6H7IRGa_FziN4x20Cn3C61y8j9nb3oFn-1P1S1hDQeojzVFYFK3iWW1agWqelZwEcATUialNZdNsdvYTIk6L5LR14P2iWhnWOlzem9s3qQmPFcsbBuYXBeBE1bd1NjtXIYHtHpNzSwa3_2G6pF786LPEUr4aZkPv_0Ol35P7R_NtUT7_Mvr4iD7ApQmG-JjvtcuXfkLvVZbu4WL7tluY1srwzHg
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lj9MwELbQ8hAX3o_yDBLXFCd27fgICxWIVbWHsuzNsmN7qbSbVG2KtP-emdgp2xVoD3CNM5Fjj8cz9sz3EfKWI74ktyZHuO6cu8DzyhuZu8IZUStjZF9Ie3QgZ7Pq-FgdpmzCdUqrxBg6RKCI3lbj4l66MGTEvYO4W1HYRsdI_T1GUqUCqayvg-ssUMnn0-_bYxbKuYx8aiiVo9hQx_O3L-3sUD2Q_yUY0z85o5dzKi9sUtO7_-H37pE7yUPN3keVuk-u-eYBuRk5K88fkqP574qtbNl2mG0Er7ch2z9tkQTELTZnmd1053i0eJbBzKGlrf0qS7kj2aLJECsbbS1IxsZH5Nv003z_c57IGfJ6wiZdXpQQmnnFHPWUWm8N-ClByMDrQinHGbXGc5gP52QdTGVFCKAElXDKgdHghj0me03b-Kck4x4cBT6xQviSG1lYJr3AAl8EL1MlHRE-TIiuE3I5Emic6iIBnA5DpnHIdBqyERlvxZYRuuMqgQ8429uXEXm7f9CuTnRayBrCWQ9RnirrYDkrJ5YKVOqi8jSAG6BGRF3UFd31By8hsqRodkUH3gyKpWGV49WNaXy7WWusVy4ZuLYwGE-iom27ybAWGSzviFQ7KrjzH7stzeJHjyRe4MUw5fLZP3T6Nbl1-HGqD77Mvj4nt7El4mC-IHvdauNfkhv1z26xXr3qF-Yv5ugx0A
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Therapeutic+potential+of+Clostridium+butyricum+anticancer+effects+in+colorectal+cancer&rft.jtitle=Gut+microbes&rft.au=Hui+Xu&rft.au=Haidan+Luo&rft.au=Jiayu+Zhang&rft.au=Kai+Li&rft.date=2023-12-31&rft.pub=Taylor+%26+Francis+Group&rft.issn=1949-0976&rft.eissn=1949-0984&rft.volume=15&rft.issue=1&rft_id=info:doi/10.1080%2F19490976.2023.2186114&rft.externalDBID=DOA&rft.externalDocID=oai_doaj_org_article_448e54892cfb4325b06a6c918e0f2129
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1949-0976&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1949-0976&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1949-0976&client=summon