Mammary tumor-derived CCL2 enhances pro-metastatic systemic inflammation through upregulation of IL1β in tumor-associated macrophages

Patients with primary solid malignancies frequently exhibit signs of systemic inflammation. Notably, elevated levels of neutrophils and their associated soluble mediators are regularly observed in cancer patients, and correlate with reduced survival and increased metastasis formation. Recently, we d...

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Vydané v:	Oncoimmunology Ročník 6; číslo 8; s. e1334744
Hlavní autori:	Kersten, Kelly, Coffelt, Seth B., Hoogstraat, Marlous, Verstegen, Niels J.M., Vrijland, Kim, Ciampricotti, Metamia, Doornebal, Chris W., Hau, Cheei-Sing, Wellenstein, Max D., Salvagno, Camilla, Doshi, Parul, Lips, Esther H., Wessels, Lodewyk F.A., de Visser, Karin E.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Taylor & Francis 03.08.2017 Taylor & Francis Group
Predmet:	Breast cancer CCL2 immunosuppression neutrophils Original Research tumor-associated macrophages tumor-induced inflammation γδ T cells γδ T cells tumor-induced inflammation CCL2 immunosuppression Breast cancer neutrophils tumor-associated macrophages
ISSN:	2162-402X, 2162-4011, 2162-402X
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