Meiotic DSB patterning: A multifaceted process

Meiosis is a specialized two-step cell division responsible for genome haploidization and the generation of genetic diversity during gametogenesis. An integral and distinctive feature of the meiotic program is the evolutionarily conserved initiation of homologous recombination (HR) by the developmen...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Cell cycle (Georgetown, Tex.) Ročník 15; číslo 1; s. 13 - 21
Hlavní autoři: Cooper, Tim J., Garcia, Valerie, Neale, Matthew J.
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Taylor & Francis 02.01.2016
Témata:
Animals
ATM
Cell Cycle Proteins - genetics
Cell Cycle Proteins - metabolism
DNA Breaks, Double-Stranded
DNA Repair - physiology
DSB competition
DSB formation
DSB hotspots
DSB interference
Extra View
Homologous Recombination - physiology
Humans
meiosis
Meiosis - physiology
recombination
Saccharomyces cerevisiae Proteins - genetics
Saccharomyces cerevisiae Proteins - metabolism
Tel1
DSB competition
DSB formation
Tel1
meiosis
recombination
DSB interference
ATM
DSB hotspots
ISSN:1538-4101, 1551-4005
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:Meiosis is a specialized two-step cell division responsible for genome haploidization and the generation of genetic diversity during gametogenesis. An integral and distinctive feature of the meiotic program is the evolutionarily conserved initiation of homologous recombination (HR) by the developmentally programmed induction of DNA double-strand breaks (DSBs). The inherently dangerous but essential act of DSB formation is subject to multiple forms of stringent and self-corrective regulation that collectively ensure fruitful and appropriate levels of genetic exchange without risk to cellular survival. Within this article we focus upon an emerging element of this control-spatial regulation-detailing recent advances made in understanding how DSBs are evenly distributed across the genome, and present a unified view of the underlying patterning mechanisms employed.
Bibliografie:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1538-4101
1551-4005
DOI:10.1080/15384101.2015.1093709