A field guide to eukaryotic circular single-stranded DNA viruses: insights gained from metagenomics

Despite their small size and limited protein-coding capacity, the rapid evolution rates of single-stranded DNA (ssDNA) viruses have led to their emergence as serious plant and animal pathogens. Recently, metagenomics has revealed an unprecedented diversity of ssDNA viruses, expanding their known env...

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Bibliographic Details
Published in:Archives of virology Vol. 157; no. 10; pp. 1851 - 1871
Main Authors: Rosario, Karyna, Duffy, Siobain, Breitbart, Mya
Format: Journal Article
Language:English
Published: Vienna Springer Vienna 01.10.2012
Springer
Springer Nature B.V
Subjects:
animal pathogens
Animals
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Brief Review
DNA Virus Infections - virology
DNA Viruses - classification
DNA Viruses - genetics
DNA Viruses - isolation & purification
DNA Viruses - metabolism
DNA, Circular - genetics
DNA, Single-Stranded - genetics
Eukaryota - virology
Evolution
Fundamental and applied biological sciences. Psychology
genome
Genomes
host range
Humans
Infectious Diseases
Medical Microbiology
metagenomics
Metagenomics - methods
Microbiology
Miscellaneous
Pathogens
Plant Diseases - virology
Proteins
Satellites
single-stranded DNA
ssDNA viruses
Viral infections
Virology
Viruses
Circular Genome
Roll Circle Replication
Rolling Circle Amplification
ssDNA Virus
Circular ssDNA
Metagenome
ISSN:0304-8608, 1432-8798, 1432-8798
Online Access:Get full text
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Summary:Despite their small size and limited protein-coding capacity, the rapid evolution rates of single-stranded DNA (ssDNA) viruses have led to their emergence as serious plant and animal pathogens. Recently, metagenomics has revealed an unprecedented diversity of ssDNA viruses, expanding their known environmental distributions and host ranges. This review summarizes and contrasts the basic characteristics of known circular ssDNA viral groups, providing a resource for analyzing the wealth of ssDNA viral sequences identified through metagenomics. Since ssDNA viruses are largely identified based on conserved rolling circle replication proteins, this review highlights distinguishing motifs and catalytic residues important for replication. Genomes identified through metagenomics have demonstrated unique ssDNA viral genome architectures and revealed characteristics that blur the boundaries between previously well-defined groups. Metagenomic discovery of ssDNA viruses has created both a challenge to current taxonomic classification schemes and an opportunity to revisit hypotheses regarding the evolutionary history of these viruses.
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ISSN:0304-8608
1432-8798
1432-8798
DOI:10.1007/s00705-012-1391-y