HDAC inhibition attenuates cardiac hypertrophy by acetylation and deacetylation of target genes

Pharmacological histone deacetylase (HDAC) inhibitors attenuate pathological cardiac remodeling and hypertrophic gene expression; yet, the direct histone targets remain poorly characterized. Since the inhibition of HDAC activity is associated with suppressing hypertrophy, we hypothesized histone ace...

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Bibliographic Details
Published in:	Epigenetics Vol. 10; no. 5; pp. 418 - 430
Main Authors:	Ooi, Jenny Y Y, Tuano, Natasha K, Rafehi, Haloom, Gao, Xiao-Ming, Ziemann, Mark, Du, Xiao-Jun, El-Osta, Assam
Format:	Journal Article
Language:	English
Published:	United States Taylor & Francis 04.05.2015
Subjects:	Acetylation - drug effects Animals Aorta - surgery cardiac hypertrophy Cardiomegaly - genetics Cardiomegaly - metabolism Cardiomegaly - surgery chromatin epigenetics Gene Expression Regulation - drug effects HDAC inhibitor histone acetylation Histone Deacetylase Inhibitors - pharmacology Histone Deacetylases - metabolism Histones - metabolism Hydroxamic Acids - pharmacology Male Mice, Inbred C57BL Myocardium - metabolism next generation sequencing NF-kappa B - metabolism Research Paper NFκB, Nuclear factor of kappa light polypeptide gene enhancer in B-cells Icam1, Intercellular adhesion molecule 1 LVH, Left Ventricle Hypertrophy cDNA, complementary DNA TF, transcription factor Il21r, Interleukin-21 receptor Serca2a, Sarcoplasmic reticulum Ca2+ ATPase TSS, Transcription Start Site epigenetics SEM, Standard Error of the Mean BW, Body Weight Il6ra, Interleukin-6 receptor Cxcl10, Chemokine (C-X-C Motif) ligand 10 FDR, False Discovery Rate NES, normalized enrichment score TAC, Transverse Aortic Constriction MACs, Model-based Analysis of ChIP-seq GAIIx, Genome Analyzer IIx Traf3, TNF receptor-associated factor 3 BNP, Brain natriuretic peptide ChIP, Chromatin Immunoprecipitation next generation sequencing NGS, Next Generation Sequencing chromatin HDAC, Histone deacetylase Vcam1, Vascular cell adhesion molecule 1 Ct, threshold cycle number TAC veh, TAC vehicle ANP, Atrial natriuretic peptide TSA, Trichostatin A HDAC inhibitor α/βMHC, Alpha/Beta myosin heavy chain ENCODE, Encyclopedia of DNA Elements Consortium FS, Fractional Shortening LVDd, Left Ventricular Diastolic Dimension UTR, Untranslated region cardiac hypertrophy Ticam2, Toll-like receptor adaptor molecule 2 histone acetylation LV, Left Ventricle TL, Tibia Length
ISSN:	1559-2294, 1559-2308
Online Access:	Get full text
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