Manipulation of Mitophagy by "All-in-One" nanosensitizer augments sonodynamic glioma therapy

Limited penetration of chemotherapeutic drugs through the blood brain barrier (BBB), and the increased chemo-resistance of glioma cells due to macroautophagy/autophagy, result in high tumor recurrence and extremely limited survival of glioma patients. Ultrasound-targeted microbubble destruction (UTM...

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Bibliographic Details
Published in:	Autophagy Vol. 16; no. 8; pp. 1413 - 1435
Main Authors:	Qu, Fei, Wang, Pan, Zhang, Kun, Shi, Yin, Li, Yixiang, Li, Chengren, Lu, Junhan, Liu, Quanhong, Wang, Xiaobing
Format:	Journal Article
Language:	English
Published:	United States Taylor & Francis 02.08.2020
Subjects:	Animals Blood brain barrier Brain Neoplasms - pathology Brain Neoplasms - therapy Cell Death - drug effects Cell Line, Tumor Cell Survival - drug effects Chlorophyllides Drug Delivery Systems Endocytosis - drug effects Female Glioma - pathology Glioma - therapy Low Density Lipoprotein Receptor-Related Protein-1 - metabolism Mice Mice, Inbred C57BL Microbubbles Mitochondria - drug effects Mitochondria - metabolism Mitochondria - ultrastructure Mitophagy - drug effects mitophagy manipulation Nanoparticles - chemistry nanosonosensitizer NIH 3T3 Cells orthotopic glioma p38 Mitogen-Activated Protein Kinases - metabolism Particle Size Peptides, Cyclic - metabolism Porphyrins - pharmacology Protein Kinases - metabolism Reactive Oxygen Species - metabolism Research Paper Signal Transduction - drug effects Somatostatin - analogs & derivatives Somatostatin - metabolism sonodynamic therapy Tissue Distribution - drug effects Ubiquitin-Protein Ligases - metabolism Ultrasonic Therapy nanosonosensitizer sonodynamic therapy mitophagy manipulation Blood brain barrier orthotopic glioma
ISSN:	1554-8627, 1554-8635, 1554-8635
Online Access:	Get full text
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