Supplemental Vitamins and Minerals for CVD Prevention and Treatment

The authors identified individual randomized controlled trials from previous meta-analyses and additional searches, and then performed meta-analyses on cardiovascular disease outcomes and all-cause mortality. The authors assessed publications from 2012, both before and including the U.S. Preventive...

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Veröffentlicht in:	Journal of the American College of Cardiology Jg. 71; H. 22; S. 2570
Hauptverfasser:	Jenkins, David J A, Spence, J David, Giovannucci, Edward L, Kim, Young-In, Josse, Robert, Vieth, Reinhold, Blanco Mejia, Sonia, Viguiliouk, Effie, Nishi, Stephanie, Sahye-Pudaruth, Sandhya, Paquette, Melanie, Patel, Darshna, Mitchell, Sandy, Kavanagh, Meaghan, Tsirakis, Tom, Bachiri, Lina, Maran, Atherai, Umatheva, Narmada, McKay, Taylor, Trinidad, Gelaine, Bernstein, Daniel, Chowdhury, Awad, Correa-Betanzo, Julieta, Del Principe, Gabriella, Hajizadeh, Anisa, Jayaraman, Rohit, Jenkins, Amy, Jenkins, Wendy, Kalaichandran, Ruben, Kirupaharan, Geithayini, Manisekaran, Preveena, Qutta, Tina, Shahid, Ramsha, Silver, Alexis, Villegas, Cleo, White, Jessica, Kendall, Cyril W C, Pichika, Sathish C, Sievenpiper, John L
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 05.06.2018
Schlagworte:	Cardiovascular Diseases - diet therapy Cardiovascular Diseases - epidemiology Cardiovascular Diseases - prevention & control Dietary Supplements Healthy Diet - methods Healthy Diet - trends Humans Randomized Controlled Trials as Topic - methods Trace Elements - administration & dosage Treatment Outcome Vitamins - administration & dosage meta-analysis supplements all-cause mortality
ISSN:	1558-3597, 1558-3597
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Beschreibung
Zusammenfassung:	The authors identified individual randomized controlled trials from previous meta-analyses and additional searches, and then performed meta-analyses on cardiovascular disease outcomes and all-cause mortality. The authors assessed publications from 2012, both before and including the U.S. Preventive Service Task Force review. Their systematic reviews and meta-analyses showed generally moderate- or low-quality evidence for preventive benefits (folic acid for total cardiovascular disease, folic acid and B-vitamins for stroke), no effect (multivitamins, vitamins C, D, β-carotene, calcium, and selenium), or increased risk (antioxidant mixtures and niacin [with a statin] for all-cause mortality). Conclusive evidence for the benefit of any supplement across all dietary backgrounds (including deficiency and sufficiency) was not demonstrated; therefore, any benefits seen must be balanced against possible risks.
Bibliographie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3
ISSN:	1558-3597 1558-3597
DOI:	10.1016/j.jacc.2018.04.020