Disruption of the immune-checkpoint VISTA gene imparts a proinflammatory phenotype with predisposition to the development of autoimmunity

V domain-containing Ig suppressor of T-cell activation (VISTA) is a negative checkpoint regulator that suppresses T cell-mediated immune responses. Previous studies using a VISTA-neutralizing monoclonal antibody show that VISTA blockade enhances T-cell activation. The current study describes a compr...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 111; no. 41; p. 14846
Main Authors:	Wang, Li, Le Mercier, Isabelle, Putra, Juan, Chen, Wenna, Liu, Jun, Schenk, Austin D, Nowak, Elizabeth C, Suriawinata, Arief A, Li, Jiannan, Noelle, Randolph J
Format:	Journal Article
Language:	English
Published:	United States 14.10.2014
Subjects:	Aging - pathology Animals Autoimmune Diseases - genetics Autoimmune Diseases - immunology Autoimmunity - genetics Autoimmunity - immunology B7 Antigens - deficiency B7 Antigens - genetics B7 Antigens - metabolism Chemokines - metabolism Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - pathology Genetic Predisposition to Disease Hematopoiesis Inflammation - pathology Lymphocyte Activation - immunology Mice, Inbred C57BL Mice, Knockout Phenotype Th1 Cells - immunology Th17 Cells - immunology peripheral tolerance autoimmunity immune suppression inflammation
ISSN:	1091-6490, 1091-6490
Online Access:	Get more information
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