An unexpected version of horror autotoxicus: anaphylactic shock to a self-peptide

EAE can refer either to experimental autoimmune encephalomyelitis or experimental allergic encephalomyelitis. Although EAE is classically a prototypic T helper 1 (T H 1) cell–mediated autoimmune disease, it can also be induced by T H 2 cells. Characteristically, the most severe manifestation of alle...

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Veröffentlicht in:	Nature immunology Jg. 2; H. 3; S. 216 - 222
Hauptverfasser:	Pedotti, Rosetta, Mitchell, Dennis, Wedemeyer, Jochen, Karpuj, Marcela, Chabas, Dorothée, Hattab, Eyas M., Tsai, Mindy, Galli, Stephen J., Steinman, Lawrence
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	New York Nature Publishing Group US 01.03.2001 Nature Publishing Group
Schlagworte:	Allergens - immunology Allergies Anaphylaxis Anaphylaxis - etiology Anaphylaxis - immunology Anaphylaxis - pathology Animals Autoantibodies - biosynthesis Autoantigens - immunology Autoimmune diseases Autoimmunity Biomedical and Life Sciences Biomedicine Encephalomyelitis, Autoimmune, Experimental - etiology Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - pathology Female Freund's Adjuvant - pharmacology Histamine - physiology Hypersensitivity Immune Tolerance Immunology Infectious Diseases Insects Mice Myelin Proteolipid Protein - immunology Peptide Fragments - immunology Peptides - immunology Serotonin - physiology Thymus Gland - immunology
ISSN:	1529-2908, 1529-2916
Online-Zugang:	Volltext
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Zusammenfassung:	EAE can refer either to experimental autoimmune encephalomyelitis or experimental allergic encephalomyelitis. Although EAE is classically a prototypic T helper 1 (T H 1) cell–mediated autoimmune disease, it can also be induced by T H 2 cells. Characteristically, the most severe manifestation of allergy, anaphylaxis, is associated with exposure to a foreign antigen that is often derived from medication, insect venom or food. We report here that, after self-tolerance to myelin is destroyed, anaphylaxis may be triggered by a self-antigen, in this case a myelin peptide. “Horror autotoxicus”, which was initially described by Ehrlich, may not only include autoimmunity to self, it may also encompass immediate hypersensitivity to self, which leads to shock and rapid death.
Bibliographie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Article-2 ObjectType-Feature-1 content type line 23
ISSN:	1529-2908 1529-2916
DOI:	10.1038/85266