Causal effect of three autoimmune diseases on brain functional networks and cerebrospinal fluid metabolites to underlie the pathogenesis of autoimmune psychosis: a two-sample mendelian randomization analysis

Background Autoimmune diseases such as Systemic Lupus Erythematosus (SLE), Sjögren’s Syndrome (SS), and Hashimoto’s Thyroiditis (HT) frequently exhibit neuropsychiatric manifestations, including cognitive impairment, depression, anxiety, and so on, yet the exact pathogenesis underlying this associat...

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Vydáno v:	Journal of translational medicine Ročník 23; číslo 1; s. 440 - 15
Hlavní autoři:	Shi, Weiman, Chen, Min, Wang, Rongai, Wen, Chengping, Huang, Lin, Wang, Qiao
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London BioMed Central 14.04.2025 BioMed Central Ltd BMC
Témata:	Autoimmune disease Autoimmune diseases Autoimmune Diseases - cerebrospinal fluid Autoimmune Diseases - complications Autoimmune Diseases - genetics Autoimmune Diseases - physiopathology Biomedical and Life Sciences Biomedicine Brain - physiopathology Causality Complications and side effects CSF metabolite Development and progression Diagnosis Genetic aspects Genome-Wide Association Study Health aspects Humans Identification and classification Magnetic Resonance Imaging Medicine/Public Health Mendelian randomization Mendelian Randomization Analysis Mental illness Metabolites Metabolomics Methods Nerve Net - physiopathology Neuroscience Phenotype Psychotic Disorders - cerebrospinal fluid Psychotic Disorders - etiology Psychotic Disorders - genetics Psychotic Disorders - physiopathology Puncture Risk factors rsfMRI Spine China Autoimmune disease CSF metabolite rsfMRI Mendelian randomization
ISSN:	1479-5876, 1479-5876
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