A central role for the ERK-signaling pathway in controlling Schwann cell plasticity and peripheral nerve regeneration in vivo

Following damage to peripheral nerves, a remarkable process of clearance and regeneration takes place. Axons downstream of the injury degenerate, while the nerve is remodeled to direct axonal regrowth. Schwann cells are important for this regenerative process. "Sensing" damaged axons, they...

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Bibliographic Details
Published in:	Neuron (Cambridge, Mass.) Vol. 73; no. 4; p. 729
Main Authors:	Napoli, Ilaria, Noon, Luke A, Ribeiro, Sara, Kerai, Ajay P, Parrinello, Simona, Rosenberg, Laura H, Collins, Melissa J, Harrisingh, Marie C, White, Ian J, Woodhoo, Ashwin, Lloyd, Alison C
Format:	Journal Article
Language:	English
Published:	United States 23.02.2012
Subjects:	Animals Animals, Newborn Benzamides - pharmacology Cell Movement - drug effects Cyclin D1 - metabolism Cytokines - metabolism Diphenylamine - analogs & derivatives Diphenylamine - pharmacology Estrogen Antagonists - pharmacology Gene Expression Regulation - drug effects Gene Expression Regulation - genetics Leukocytes - pathology Male MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - genetics MAP Kinase Signaling System - physiology Mast Cells - pathology Mice Mice, Inbred C57BL Mice, Transgenic Microscopy, Confocal Microscopy, Electron, Transmission Microscopy, Immunoelectron Motor Activity - drug effects Motor Activity - genetics Myelin Sheath - genetics Myelin Sheath - metabolism Nerve Regeneration - drug effects Nerve Regeneration - genetics Neutrophils - metabolism Neutrophils - pathology Peripheral Nerve Injuries - pathology Peripheral Nerve Injuries - physiopathology Proto-Oncogene Proteins c-raf - genetics Proto-Oncogene Proteins c-raf - metabolism Reaction Time - drug effects Reaction Time - genetics Receptor, Nerve Growth Factor - genetics Receptor, Nerve Growth Factor - metabolism Receptors, Estrogen - genetics Recovery of Function - drug effects Recovery of Function - genetics Schwann Cells - physiology Schwann Cells - ultrastructure T-Lymphocytes - metabolism T-Lymphocytes - pathology Tamoxifen - pharmacology Time Factors
ISSN:	1097-4199, 1097-4199
Online Access:	Get more information
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