Identification and characterization of enhancers controlling the inflammatory gene expression program in macrophages

Enhancers determine tissue-specific gene expression programs. Enhancers are marked by high histone H3 lysine 4 mono-methylation (H3K4me1) and by the acetyl-transferase p300, which has allowed genome-wide enhancer identification. However, the regulatory principles by which subsets of enhancers become...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Jg. 32; H. 3; S. 317
Hauptverfasser:	Ghisletti, Serena, Barozzi, Iros, Mietton, Flore, Polletti, Sara, De Santa, Francesca, Venturini, Elisa, Gregory, Lorna, Lonie, Lorne, Chew, Adeline, Wei, Chia-Lin, Ragoussis, Jiannis, Natoli, Gioacchino
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 26.03.2010
Schlagworte:	Animals Binding Sites Cells, Cultured Chromatin - immunology Chromatin - metabolism E1A-Associated p300 Protein - genetics E1A-Associated p300 Protein - metabolism Female Gene Expression Profiling Gene Expression Regulation Inflammation - genetics Inflammation - immunology Inflammation - metabolism Lipopolysaccharides - immunology Macrophages - immunology Macrophages - metabolism Mice Protein Binding Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Regulatory Sequences, Nucleic Acid Trans-Activators - genetics Trans-Activators - metabolism
ISSN:	1097-4180, 1097-4180
Online-Zugang:	Weitere Angaben
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