The influence of family history of Hypertension on disease prevalence and associated metabolic risk factors among Sri Lankan adults

Background Hypertension is a major contributor to the global non-communicable disease burden. Family history is an important non-modifiable risk factor for hypertension. The present study aims to describe the influence of family history (FH) on hypertension prevalence and associated metabolic risk f...

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Bibliographic Details
Published in:BMC public health Vol. 15; no. 1; p. 576
Main Authors: Ranasinghe, Priyanga, Cooray, Dilini N., Jayawardena, Ranil, Katulanda, Prasad
Format: Journal Article
Language:English
Published: London BioMed Central 20.06.2015
BioMed Central Ltd
Springer Nature B.V
Subjects:
Adult
Adults
Biostatistics
Blood pressure
Body Mass Index
Body size
Children
Communicable diseases
Comorbidity
Cross-Sectional Studies
Dependent variables
Diabetes
Diabetes mellitus
Diabetes Mellitus - epidemiology
Environmental Health
Epidemiology
Ethnicity
Exercise
Families & family life
Family Health
Family medical history
Female
Genetics
Grandparents
Heavy metals
Humans
Hyperlipidemia
Hypertension
Hypertension - epidemiology
Independent variables
Industrialized nations
Male
Medical research
Medicine
Medicine & Public Health
Medicine, Experimental
Metabolic disorders
Metabolic syndrome
Metabolic Syndrome - epidemiology
Metabolism
Middle Aged
Obesity
Obesity - epidemiology
Obesity, Abdominal - epidemiology
Odds Ratio
Parents
Parents & parenting
Physical activity
Prevalence
Public Health
Questionnaires
Regression analysis
Research Article
Risk Factors
Rural areas
Siblings
Socioeconomic Factors
Sri Lanka - epidemiology
Vaccine
Variables
Young Adult
United Kingdom > UK
Sri Lanka
South Asia
Hypertension
Adults
Prevalence
Sri Lanka
Family history
ISSN:1471-2458, 1471-2458
Online Access:Get full text
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Summary:Background Hypertension is a major contributor to the global non-communicable disease burden. Family history is an important non-modifiable risk factor for hypertension. The present study aims to describe the influence of family history (FH) on hypertension prevalence and associated metabolic risk factors in a large cohort of South Asian adults, from a nationally representative sample from Sri Lanka. Methods A cross-sectional survey among 5,000 Sri Lankan adults, evaluating FH at the levels of parents, grandparents, siblings and children. A binary logistic regression analysis was performed in all patients with ‘presence of hypertension’ as dichotomous dependent variable and using family history in parents, grandparents, siblings and children as binary independent variables. The adjusted odds ratio controlling for confounders (age, gender, body mass index, diabetes, hyperlipidemia and physical activity) are presented below. Results In all adults the prevalence of hypertension was significantly higher in patients with a FH (29.3 %, n = 572/1951) than those without (24.4 %, n = 616/2530) (p < 0.001). Presence of a FH significantly increased the risk of hypertension (OR:1.29; 95 % CI:1.13-1.47), obesity (OR:1.36; 95 % CI: 1.27–1.45), central obesity (OR:1.30; 95 % CI 1.22–1.40) and metabolic syndrome (OR:1.19; 95 % CI: 1.08–1.30). In all adults presence of family history in parents (OR:1.28; 95 % CI: 1.12–1.48), grandparents (OR:1.34; 95 % CI: 1.20–1.50) and siblings (OR:1.27; 95 % CI: 1.21–1.33) all were associated with significantly increased risk of developing hypertension. Conclusions Our results show that the prevalence of hypertension was significantly higher in those with a FH of hypertension. FH of hypertension was also associated with the prevalence of obesity, central obesity and metabolic syndrome. Individuals with a FH of hypertension form an easily identifiable group who may benefit from targeted interventions.
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ISSN:1471-2458
1471-2458
DOI:10.1186/s12889-015-1927-7